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Protocols for copying and proofreading in template-assisted polymerization
dc.contributor.author | Pigolotti, Simone |
dc.contributor.author | Sartori, Pablo |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Física |
dc.date.accessioned | 2016-04-11T15:26:19Z |
dc.date.available | 2017-03-31T00:30:44Z |
dc.date.issued | 2016-03 |
dc.identifier.citation | Pigolotti, S., Sartori, P. Protocols for copying and proofreading in template-assisted polymerization. "Journal of statistical physics", Març 2016, vol. 162, núm. 5, p. 1167-1182. |
dc.identifier.issn | 0022-4715 |
dc.identifier.uri | http://hdl.handle.net/2117/85517 |
dc.description.abstract | We discuss how information encoded in a template polymer can be stochastically copied into a copy polymer. We consider four different stochastic copy protocols of increasing complexity, inspired by building blocks of the mRNA translation pathway. In the rst protocol, monomer incorporation occurs in a single stochastic transition. We then move to a more elaborate protocol in which an intermediate step can be used for error correction. Finally, we discuss the operating regimes of two kinetic proofreading protocols: one in which proofreading acts from the nal copying step, and one in which it acts from an intermediate step. We review known results for these models and, in some cases, extend them to analyze all possible combinations of energetic and kinetic discrimination. We show that, in each of these protocols, only a limited number of these combinations leads to an improvement of the overall copying accuracy |
dc.format.extent | 16 p. |
dc.language.iso | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria química |
dc.subject.lcsh | Polymerization |
dc.subject.lcsh | Polymer engineering |
dc.subject.other | Keywords: kinetic proofreading |
dc.subject.other | biological copying |
dc.subject.other | polymerization |
dc.subject.other | speed- accuracy trade-off |
dc.title | Protocols for copying and proofreading in template-assisted polymerization |
dc.type | Article |
dc.subject.lemac | Polimerització |
dc.subject.lemac | Polímers |
dc.contributor.group | Universitat Politècnica de Catalunya. DONLL - Dinàmica no Lineal, Òptica no Lineal i Làsers |
dc.identifier.doi | 10.1007/s10955-015-1399-2 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://link.springer.com/article/10.1007%2Fs10955-015-1399-2 |
dc.rights.access | Open Access |
local.identifier.drac | 17555343 |
dc.description.version | Postprint (published version) |
local.citation.author | Pigolotti, S.; Sartori, P. |
local.citation.publicationName | Journal of statistical physics |
local.citation.volume | 162 |
local.citation.number | 5 |
local.citation.startingPage | 1167 |
local.citation.endingPage | 1182 |
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