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Anhydride-functional silane immobilized onto titanium surfaces induces osteoblast cell differentiation and reduces bacterial adhesion and biofilm formation
dc.contributor.author | Godoy Gallardo, Maria |
dc.contributor.author | Guillem Martí, Jordi |
dc.contributor.author | Sevilla Sánchez, Pablo |
dc.contributor.author | Manero Planella, José María |
dc.contributor.author | Gil Mur, Francisco Javier |
dc.contributor.author | Rodríguez Rius, Daniel |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica |
dc.date.accessioned | 2016-04-11T11:30:18Z |
dc.date.available | 2018-02-01T01:30:39Z |
dc.date.issued | 2016-02-01 |
dc.identifier.citation | Godoy, M., Guillem-Marti, J., Sevilla, P., Manero, J., Gil, F.J., Rodriguez, D. Anhydride-functional silane immobilized onto titanium surfaces induces osteoblast cell differentiation and reduces bacterial adhesion and biofilm formation. "Materials science and engineering C. Biomimetic and supramolecular systems", 01 Febrer 2016, vol. 59, p. 524-532. |
dc.identifier.issn | 0928-4931 |
dc.identifier.uri | http://hdl.handle.net/2117/85475 |
dc.description.abstract | Bacterial infection in dental implants along with osseointegration failure usually leads to loss of the device. Bioactive molecules with antibacterial properties can be attached to titanium surfaces with anchoring molecules such as silanes, preventing biofilm formation and improving osseointegration. Properties of silanes as molecular binders have been thoroughly studied, but research on the biological effects of these coatings is scarce. The aim of the present study was to determine the in vitro cell response and antibacterial effects of triethoxysilypropyl succinic anhydride (TESPSA) silane anchored on titanium surfaces. X-ray photoelectron spectroscopy confirmed a successful silanization. The silanized surfaces showed no cytotoxic effects. Gene expression analyses of Sarcoma Osteogenic (SaOS-2) osteoblast-like cells cultured on TESPSA silanized surfaces reported a remarkable increase of biochemical markers related to induction of osteoblastic cell differentiation. A manifest decrease of bacterial adhesion and biofilm formation at early stages was observed on treated substrates, while favoring cell adhesion and spreading in bacteria-cell co-cultures.; Surfaces treated with TESPSA could enhance a biological sealing on implant surfaces against bacteria colonization of underlying tissues. Furthermore, it can be an effective anchoring platform of biomolecules on titanium surfaces with improved osteoblastic differentiation and antibacterial properties. (C) 2015 Elsevier B.V. All rights reserved. |
dc.format.extent | 9 p. |
dc.language.iso | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria dels materials |
dc.subject.lcsh | Biofilms |
dc.subject.lcsh | Biomedical materials |
dc.subject.lcsh | Titanium |
dc.subject.other | Bacterial adhesion |
dc.subject.other | Biofilm |
dc.subject.other | Osteoblast differentiation |
dc.subject.other | Silane |
dc.subject.other | Titanium |
dc.subject.other | tissue integration |
dc.subject.other | silanization |
dc.subject.other | biomaterial |
dc.subject.other | growth |
dc.subject.other | energy |
dc.subject.other | 3-aminopropyltriethoxysilane |
dc.subject.other | attachment |
dc.subject.other | expression |
dc.subject.other | roughness |
dc.subject.other | peptide |
dc.title | Anhydride-functional silane immobilized onto titanium surfaces induces osteoblast cell differentiation and reduces bacterial adhesion and biofilm formation |
dc.type | Article |
dc.subject.lemac | Biofilms |
dc.subject.lemac | Titani -- Aplicacions mèdiques |
dc.contributor.group | Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits |
dc.identifier.doi | 10.1016/j.msec.2015.10.051 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0928493115304823 |
dc.rights.access | Open Access |
local.identifier.drac | 17546739 |
dc.description.version | Postprint (author's final draft) |
dc.relation.projectid | info:eu-repo/grantAgreement/MINECO//MAT2012-30706/ES/NUEVOS BIOMATERIALES METALICOS BIOFUNCIONALIZADOS PARA APLICACIONES ORTOPEDICAS, DENTALES Y CARDIOVASCULARES/ |
local.citation.author | Godoy, M.; Guillem-Marti, J.; Sevilla, P.; Manero, J.; Gil, F.J.; Rodriguez, D. |
local.citation.publicationName | Materials science and engineering C. Biomimetic and supramolecular systems |
local.citation.volume | 59 |
local.citation.startingPage | 524 |
local.citation.endingPage | 532 |
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