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dc.contributor.authorFrancesko, Antonio
dc.contributor.authorMacedo Fernandes, Margarida Maria
dc.contributor.authorIvanova, Kristina Dimitrova
dc.contributor.authorTzanov, Tzanko
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2016-02-01T09:28:43Z
dc.date.available2018-01-19T01:30:42Z
dc.date.issued2016-01-21
dc.identifier.citationFrancesko, A., Macedo, M.M., Ivanova, K., Tzanov, T. Bacteria-responsive multilayer coatings comprising polycationic nanospheres for bacteria biofilm prevention on urinary catheters. "Acta biomaterialia", 21 Gener 2016.
dc.identifier.issn1742-7061
dc.identifier.urihttp://hdl.handle.net/2117/82331
dc.description.abstractThis work reports on the development of infection-preventive coatings on silicone urinary catheters that contain in their structure and release on demand antibacterial polycationic nanospheres. Polycationic aminocellulose conjugate was first sonochemically processed into nanospheres to improve its antibacterial potential compared to the bulk conjugate in solution (ACSol). Afterward the processed aminocellulose nanospheres (ACNSs) were combined with the hyaluronic acid (HA) polyanion to build a layer-by-layer construct on silicone surfaces. Although the coating deposition was more effective when HA was coupled with ACSol than with ACNSs, the ACNSs-based coatings were thicker and displayed smoother surfaces due to the embedment of intact nanospheres. The antibacterial effect of ACNSs multilayers was 40% higher compared to ACSol coatings. This fact was further translated into more effective prevention of Pseudomonas aeruginosa biofilm formation. The coatings were stable in the absence of bacteria, whereas their disassembling occurred gradually during incubation with P. aeruginosa, and thus eradicate the biofilm upon release of antibacterial agents. Only 5 bilayers of HA/ACNSs were sufficient to prevent the biofilm formation, in contrast to the 10 bilayers of ACSol required to achieve the same effect. The antibiofilm efficiency of (HA/ACNSs)10 multilayer construct built on a Foley catheter was additionally validated under dynamic conditions using a model of the catheterized bladder in which the biofilm was grown during seven days
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshCatheters
dc.subject.lcshBiofilms
dc.titleBacteria-responsive multilayer coatings comprising polycationic nanospheres for bacteria biofilm prevention on urinary catheters
dc.typeArticle
dc.subject.lemacCatèters
dc.subject.lemacBacteris
dc.contributor.groupUniversitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial
dc.identifier.doi10.1016/j.actbio.2016.01.020
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1742706116300204
dc.rights.accessOpen Access
local.identifier.drac17415041
dc.description.versionPostprint (author's final draft)
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/FP7/331416/EU/Novel coatings to prevent biofilm formation on urinary catheters based on nanoantibiotics and quorum quenching compounds/NANOQUENCH
local.citation.authorFrancesko, A.; Macedo, M.M.; Ivanova, K.; Tzanov, T.
local.citation.publicationNameActa biomaterialia


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