Enviaments recents

  • Towards efficient data exchange and sharing for big-data driven materials science: metadata and data formats 

    Ghiringhelli, Luca M.; Carbogno, Christian; Levchenko, Sergey; Mohamed, Fawzi; Huhs, Georg; Lüders, Martin; Oliveira, Micael; Scheffler, Matthias (Nature Publishing Group, 2017-11-06)
    Article
    Accés obert
    With big-data driven materials research, the new paradigm of materials science, sharing and wide accessibility of data are becoming crucial aspects. Obviously, a prerequisite for data exchange and big-data analytics is ...
  • The ins and outs of vanillyl alcohol oxidase: Identification of ligand migration paths 

    Gygli, Gudrun; Lucas, Maria F.; Guallar, Victor; van Berkel, Willhem J.H. (Public Library of Science, 2017-10-06)
    Article
    Accés obert
    Vanillyl alcohol oxidase (VAO) is a homo-octameric flavoenzyme belonging to the VAO/PCMH family. Each VAO subunit consists of two domains, the FAD-binding and the cap domain. VAO catalyses, among other reactions, the ...
  • Automatic identification of informative regions with epigenomic changes associated to hematopoiesis 

    Carrillo-de-Santa-Pau, Enrique; Juan, David; Pancaldi, Vera; Were, Felipe; Martin-Subero, Ignacio; Rico, Daniel; Valencia, Alfonso (Oxford University Press, 2017-09-19)
    Article
    Accés obert
    Hematopoiesis is one of the best characterized biological systems but the connection between chromatin changes and lineage differentiation is not yet well understood. We have developed a bioinformatic workflow to generate ...
  • The Influence of Autumnal Eurasian Snow Cover on Climate and Its Link with Arctic Sea Ice Cover 

    Gastineau, Guillaume; García-Serrano, Javier; Frankignoul, Claude (American Meteorological Society, 2017-08)
    Article
    Accés obert
    The relationship between Eurasian snow cover extent (SCE) and Northern Hemisphere atmospheric circulation is studied in reanalysis during 1979–2014 and in CMIP5 preindustrial control runs. In observations, dipolar SCE ...
  • The Functional Impact of Alternative Splicing in Cancer 

    Climente-Gonzalez, Héctor; Porta-Pardo, Eduard; Godzik, Adam; Eyras, Eduardo (Elsevier (Cell Press), 2017-08-29)
    Article
    Accés obert
    Alternative splicing changes are frequently observed in cancer and are starting to be recognized as important signatures for tumor progression and therapy. However, their functional impact and relevance to tumorigenesis ...
  • The biomedical abbreviation recognition and resolution (BARR) track: Benchmarking, evaluation and importance of abbreviation recognition systems applied to Spanish biomedical abstracts 

    Intxaurrondo, Ander; Pérez-Pérez, Martin; Pérez-Rodríguez, Gael; López-Martín, Jose A.; Santamaria, Jesus; de la Peña, Santiago; Villegas, Marta; Akhondi, Saber A.; Valencia, Alfonso; Lourenço, Analia; Krallinger, Martin (2017-09-19)
    Accés obert
    Healthcare professionals are generating a substantial volume of clinical data in narrative form. As healthcare providers are confronted with serious time constraints, they frequently use telegraphic phrases, domain-specific ...
  • Inhibition of Human Enhancer of Zeste Homolog 2 (EZH2) with Tambjamine Analogs 

    Kotev, Martin; Manuel-Manresa, Pilar; Hernando, Elsa; Soto-Cerrato, Vanessa; Orozco, Modesto; Quesada, Roberto; Pérez-Tomás, Ricardo; Guallar, Victor (American Chemical Society, 2017-08-01)
    Article
    Accés restringit per política de l'editorial
    Combining computational modeling, de novo compound synthesis, and in vitro and cellular assays, we have performed an inhibition study against the enhancer of zeste homolog 2 (EZH2) histone-lysine N-methyltransferase. This ...
  • Lessons Learned: Recommendations for Establishing Critical Periodic Scientific Benchmarking 

    Capella-Gutierrez, Salvador; de la Iglesia, Diana; Haas, Juergen; Lourenco, Analia; Fernandez, José M.; Repchevsky, Dmitry; Dessimoz, Christophe; Schwede, Torsten; Notredame, Cedric; Gelpi, Josep Ll.; Valencia, Alfonso (2017)
    Working paper
    Accés obert
    The dependence of life scientists on software has steadily grown in recent years. For many tasks, researchers have to decide which of the available bioinformatics software are more suitable for their specific needs. ...
  • Docking-based modeling of protein-protein interfaces for extensive structural and functional characterization of missense mutations 

    Barradas-Bautista, Didier; Fernández-Recio, Juan (Public Library of Science, 2017-08-25)
    Article
    Accés obert
    Next-generation sequencing (NGS) technologies are providing genomic information for an increasing number of healthy individuals and patient populations. In the context of the large amount of generated genomic data that is ...
  • Comparison of algorithms for the detection of cancer drivers at subgene resolution 

    Porta-Pardo, Eduard; Kamburov, Atanas; Tamborero, David; Pons, Tirso; Grases, Daniela; Valencia, Alfonso; Lopez-Bigas, Nuria; Getz, Gad; Godzik, Adam (Nature Publishing Group, 2017-08)
    Article
    Accés restringit per política de l'editorial
    Understanding genetic events that lead to cancer initiation and progression remains one of the biggest challenges in cancer biology. Traditionally, most algorithms for cancer-driver identification look for genes that have ...

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