Enviaments recents

  • The Functional Impact of Alternative Splicing in Cancer 

    Climente-Gonzalez, Héctor; Porta-Pardo, Eduard; Godzik, Adam; Eyras, Eduardo (Elsevier (Cell Press), 2017-08-29)
    Article
    Accés obert
    Alternative splicing changes are frequently observed in cancer and are starting to be recognized as important signatures for tumor progression and therapy. However, their functional impact and relevance to tumorigenesis ...
  • The biomedical abbreviation recognition and resolution (BARR) track: Benchmarking, evaluation and importance of abbreviation recognition systems applied to Spanish biomedical abstracts 

    Intxaurrondo, Ander; Pérez-Pérez, Martin; Pérez-Rodríguez, Gael; López-Martín, Jose A.; Santamaria, Jesus; de la Peña, Santiago; Villegas, Marta; Akhondi, Saber A.; Valencia, Alfonso; Lourenço, Analia; Krallinger, Martin (2017-09-19)
    Accés obert
    Healthcare professionals are generating a substantial volume of clinical data in narrative form. As healthcare providers are confronted with serious time constraints, they frequently use telegraphic phrases, domain-specific ...
  • Inhibition of Human Enhancer of Zeste Homolog 2 (EZH2) with Tambjamine Analogs 

    Kotev, Martin; Manuel-Manresa, Pilar; Hernando, Elsa; Soto-Cerrato, Vanessa; Orozco, Modesto; Quesada, Roberto; Pérez-Tomás, Ricardo; Guallar, Victor (American Chemical Society, 2017-08-01)
    Article
    Accés restringit per política de l'editorial
    Combining computational modeling, de novo compound synthesis, and in vitro and cellular assays, we have performed an inhibition study against the enhancer of zeste homolog 2 (EZH2) histone-lysine N-methyltransferase. This ...
  • Lessons Learned: Recommendations for Establishing Critical Periodic Scientific Benchmarking 

    Capella-Gutierrez, Salvador; de la Iglesia, Diana; Haas, Juergen; Lourenco, Analia; Fernandez, José M.; Repchevsky, Dmitry; Dessimoz, Christophe; Schwede, Torsten; Notredame, Cedric; Gelpi, Josep Ll.; Valencia, Alfonso (2017)
    Working paper
    Accés obert
    The dependence of life scientists on software has steadily grown in recent years. For many tasks, researchers have to decide which of the available bioinformatics software are more suitable for their specific needs. ...
  • Docking-based modeling of protein-protein interfaces for extensive structural and functional characterization of missense mutations 

    Barradas-Bautista, Didier; Fernández-Recio, Juan (Public Library of Science, 2017-08-25)
    Article
    Accés obert
    Next-generation sequencing (NGS) technologies are providing genomic information for an increasing number of healthy individuals and patient populations. In the context of the large amount of generated genomic data that is ...
  • Comparison of algorithms for the detection of cancer drivers at subgene resolution 

    Porta-Pardo, Eduard; Kamburov, Atanas; Tamborero, David; Pons, Tirso; Grases, Daniela; Valencia, Alfonso; Lopez-Bigas, Nuria; Getz, Gad; Godzik, Adam (Nature Publishing Group, 2017-08)
    Article
    Accés restringit per política de l'editorial
    Understanding genetic events that lead to cancer initiation and progression remains one of the biggest challenges in cancer biology. Traditionally, most algorithms for cancer-driver identification look for genes that have ...
  • Adaptive simulations, towards interactive protein-ligand modeling 

    Lecina, Daniel; Gilabert, Joan F.; Guallar, Victor (2017-08-16)
    Article
    Accés obert
    Modeling the dynamic nature of protein-ligand binding with atomistic simulations is one of the main challenges in computational biophysics, with important implications in the drug design process. Although in the past few ...
  • Molecular Modeling in Enzyme Design, Toward In Silico Guided Directed Evolution 

    Monza, Emanuele; Acebes, Sandra; Lucas, Fátima; Guallar, Victor (Springer, 2017-02-15)
    Capítol de llibre
    Accés restringit per política de l'editorial
    Directed evolution (DE) creates diversity in subsequent rounds of mutagenesis in the quest of increased protein stability, substrate binding, and catalysis. Although this technique does not require any structural/mechanistic ...
  • Oxidoreductases on their way to industrial biotransformations 

    Martinez, Angel T.; Ruiz-Dueñas, Francisco; Camarero, Susana; Serrano, Ana; Linde, Dolores; Lund, Henrik; Vind, Jesper; Tovborg, Morten; Herold-Majumdar, Owik M.; Hofrichter, Martin; Liers, Christiane; Ullrich, René; Scheibner, Katrin; Sannia, Giovanni; Piscitelli, Alessandra; Pezzella, Cinzia; Sener, Mehmet E.; Kiliç, Sibel; van Berkel, Willhem J.H.; Guallar, Victor; Lucas, Fátima; Zuhse, Ralf; Ludwig, Roland; Hollmann, Frank; Fernández-Fueyo, Elena; Record, Eric; Faulds, Craig B.; Tortajada, Marta; Winckelmann, Ib; Rasmussen, Jo-Anne; Gelo-Pujic, Mirjana; Gutiérrez, Ana; del Río, José C.; Rencoret, Jorge; Alcalde, Miguel (Elsevier, 2017-11)
    Article
    Accés obert
    Fungi produce heme-containing peroxidases and peroxygenases, flavin-containing oxidases and dehydrogenases, and different copper-containing oxidoreductases involved in the biodegradation of lignin and other recalcitrant ...
  • Information Retrieval and Text Mining Technologies for Chemistry 

    Krallinger, Martin; Rabal, Obdulia; Lourenço, Anália; Oyarzabal, Julen; Valencia, Alfonso (American Chemical Society, 2017-05-05)
    Article
    Accés restringit per política de l'editorial
    Efficient access to chemical information contained in scientific literature, patents, technical reports, or the web is a pressing need shared by researchers and patent attorneys from different chemical disciplines. Retrieval ...

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