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Physical principles of membrane remodelling during cell mechanoadaptation
dc.contributor.author | Casares, Laura |
dc.contributor.author | Elosegui Artola, Alberto |
dc.contributor.author | Arroyo Balaguer, Marino |
dc.contributor.author | Navajas, Daniel |
dc.contributor.author | Roca Cusachs, Pere |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental |
dc.date.accessioned | 2015-11-30T12:25:19Z |
dc.date.available | 2015-11-30T12:25:19Z |
dc.date.issued | 2015-06-01 |
dc.identifier.citation | Casares, L., Elosegui, A., Arroyo, M., Navajas, D., Roca, P. Physical principles of membrane remodelling during cell mechanoadaptation. "Nature communications", 01 Juny 2015, vol. 6, núm. 7292, p. 1-11. |
dc.identifier.issn | 2041-1723 |
dc.identifier.uri | http://hdl.handle.net/2117/80032 |
dc.description.abstract | Biological processes in any physiological environment involve changes in cell shape, which must be accommodated by their physical envelope-the bilayer membrane. However, the fundamental biophysical principles by which the cell membrane allows for and responds to shape changes remain unclear. Here we show that the 3D remodelling of the membrane in response to a broad diversity of physiological perturbations can be explained by a purely mechanical process. This process is passive, local, almost instantaneous, before any active remodelling and generates different types of membrane invaginations that can repeatedly store and release large fractions of the cell membrane. We further demonstrate that the shape of those invaginations is determined by the minimum elastic and adhesive energy required to store both membrane area and liquid volume at the cell-substrate interface. Once formed, cells reabsorb the invaginations through an active process with duration of the order of minutes. |
dc.format.extent | 11 p. |
dc.language.iso | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències |
dc.subject.lcsh | Biomathematics |
dc.subject.other | ALVEOLAR EPITHELIAL-CELLS |
dc.subject.other | SURFACE-AREA REGULATION |
dc.subject.other | LIVING CELLS |
dc.subject.other | TENSION |
dc.subject.other | DYNAMICS |
dc.subject.other | SHAPE |
dc.subject.other | EXOCYTOSIS |
dc.subject.other | MIGRATION |
dc.subject.other | NEURONS |
dc.subject.other | STRESS |
dc.title | Physical principles of membrane remodelling during cell mechanoadaptation |
dc.type | Article |
dc.subject.lemac | Biologia -- Models matemàtics |
dc.contributor.group | Universitat Politècnica de Catalunya. LACÀN - Mètodes Numèrics en Ciències Aplicades i Enginyeria |
dc.identifier.doi | 10.1038/ncomms8292 |
dc.description.peerreviewed | Peer Reviewed |
dc.subject.ams | Classificació AMS::92 Biology and other natural sciences::92B Mathematical biology in general |
dc.relation.publisherversion | https://www.nature.com/articles/ncomms8292 |
dc.rights.access | Open Access |
local.identifier.drac | 16827726 |
dc.description.version | Postprint (published version) |
dc.relation.projectid | info:eu-repo/grantAgreement/EC/FP7/242993/EU/Physical Forces Driving Collective Cell Migration: from Genes to Mechanism/GENESFORCEMOTION |
dc.relation.projectid | info:eu-repo/grantAgreement/EC/FP7/240487/EU/Predictive models and simulations in nano- and biomolecular mechanics: a multiscale approach/PREDMODSIM |
dc.relation.projectid | info:eu-repo/grantAgreement/EC/FP7/303848/EU/Mechanical pathways in cells: from molecular mechanisms to cell function/MECPATH |
local.citation.author | Casares, L.; Elosegui, A.; Arroyo, M.; Navajas, D.; Roca, P. |
local.citation.publicationName | Nature communications |
local.citation.volume | 6 |
local.citation.number | 7292 |
local.citation.startingPage | 1 |
local.citation.endingPage | 11 |
dc.identifier.pmid | 26073653 |
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