El GRBIO és un grup interdisciplinari amb interessos diversos tant metodològics com aplicats amb una base comuna que és l'aplicació rigorosa de l'estadística a problemes suscitats a les Ciències de la Vida i de la Salut. Les activitats científiques les agrupem en tres àmbits:
1) Assajos clínics: aportacions metodològiques en les fases de disseny i modelat estadístic;
2) Anàlisi integrativa de dades òmiques: mètodes estadístics multivariants i de "machine learning";
3) Desenvolupament d'eines estadístiques i informàtiques per l'explotació dels resultats de la recerca biomèdica.
Mencionem també les contribucions a l'anàlisi i representació de dades multivariants, a l'anàlisi de dades de supervivència amb censura en un interval, a l'optimització del disseny de fàrmacs amb simulació i a la resolució de problemes aplicats en camps com VIH/SIDA, oncologia, neurociències, cardiologia o immunologia.

http://futur.upc.edu/GRBIO

The group's objectives are as follows: to develop new statistical inference methods; to adapt existing methods to new contexts; and to work on interdisciplinary applications that require non-standard statistical analysis.

http://futur.upc.edu/GRBIO

The group's objectives are as follows: to develop new statistical inference methods; to adapt existing methods to new contexts; and to work on interdisciplinary applications that require non-standard statistical analysis.

http://futur.upc.edu/GRBIO

Enviaments recents

  • Identification of interleukin-27 (IL-27)/IL-27 receptor subunit alpha as a critical immune axis for in vivo hiv control 

    Ruiz-Riol, M.; Berdnik, D.; Llano, A.; Mothe, Beatriz; Gálvez, C.; Pérez Alvarez, Susana; Oriol Tordera, B.; Olvera Van der Stoep, Alex; Silva Arrieta, S.; Meulbroek, M.; Salvat Pujol, Francesc; Coll, J.; Martínez Picado, Javier; Ganoza, Carmela; Sánchez, J.; Gómez Melis, Guadalupe; Coray, Wyss; Brander, Christian (2017-08-01)
    Article
    Accés obert
    Intact and broad immune cell effector functions and specific individual cytokines have been linked to HIV disease outcome, but their relative contribution to HIV control remains unclear. We asked whether the proteome of ...
  • Interventions to improve adherence to reporting guidelines in health research: a scoping review protocol 

    Blanco de Tena Davila, David; Kirkham, Jamie; Altman, D.G.; Moher, David; Boutron, Isabelle; Cobo Valeri, Erik (2017-11-16)
    Article
    Accés obert
    There is evidence that the use of some reporting guidelines, such as the Consolidated Standards for Reporting Trials, is associated with improved completeness of reporting in health research. However, the current levels ...
  • The use of a binary composite endpoint and sample size requirement: influence of endpoints overlap 

    Ramon Marsal, Josep; Ferreira González, Ignacio; Bertrán, Sandra; Ribera, Aida; Permanyer-Miralda, Gaietà; Garcia Dorado, Antonio David; Gómez Melis, Guadalupe (2017-04-10)
    Article
    Accés restringit per política de l'editorial
    Although composite endpoints (CE) are common in clinical trials, the impact of the relationship between the components of a binary CE on the sample size requirement (SSR) has not been addressed. We performed a computational ...
  • Identification of Interleukin-27 (IL-27)/IL- 27 Receptor Subunit Alpha as a Critical Immune Axis for In Vivo HIV Control 

    Ruiz-Riol, M.; Berdnik, D.; Llano, A.; Mothe, Beatriz; Gálvez Montón, Carolina; Pérez Alvarez, Susana; Oriol Tordera, B.; Olvera Van der Stoep, Alex; Silva Arrieta, S.; Meulbroek, M.; Pujol, F.; Coll, J.; Martínez Picado, Javier; Ganoza, Carmela; Sánchez, J.; Gómez Melis, Guadalupe; Coray, Wyss; Brander, Christian (2017-08)
    Article
    Accés obert
    Intact and broad immune cell effector functions and specific individual cytokines have been linked to HIV disease outcome, but their relative contribution to HIV control remains unclear. We asked whether the proteome of ...
  • Escala de gravedad de daños en edificios : de la asignación directa a la contrastación estadística 

    Ruiz Gorrindo, Félix; Aguado de Cea, Antonio; Serrat Piè, Carles (2017-02)
    Article
    Accés obert
    Para llevar a cabo el mantenimiento preventivo de los edificios de una manera eficaz es importante contar con una escala unificada de posibles defi ciencias existentes. Esta es la hipótesis que los autores plantean a continuación
  • Impact of protease inhibitors on the evolution of urinary markers: subanalyses from an observational cross-sectional study 

    Bonjoch Badia, Anna; Puig, Jordi; Pérez Álvarez, Nuria; Juega Mariño, Javier; Echeverria Liras, Patricia; Clotet Sala, Bonaventura; Romero, Ramon; Bonet, Josep; Negredo Puigmal, Eugènia (2016-08)
    Article
    Accés obert
    Kidney injury (defined as the presence of albuminuria, proteinuria, glycosuria [without hyperglycemia], hematuria, and/or renal hypophosphatemia) is an emerging problem in human immunodeficiency virus (HIV)-infected patients, ...
  • Prospective study to assess progression of renal markers after interruption of tenofovir due to nephrotoxicity 

    Bonjoch Badia, Anna; Echeverria Liras, Patricia; Pérez Álvarez, Nuria; Puig, Jordi; Estany Quera, Carla; Clotet Sala, Bonaventura; Negredo Puigmal, Eugènia (2016)
    Article
    Accés obert
    Background. Prospective studies about the reversibility of tenofovir disoproxil fumarate- (TDF-) related renal impairment remain scarce. Methods. This is an observational prospective study including all patients that ...
  • Withdrawing inactive NRTIs in HIV-1 subjects with suppressed viraemia: a randomized trial 

    Llibre, Josep M.; Àlvarez Suau, Maria Hortènsia; Antela, Antonio; Toro, Jessica; Payeras, Antoni; Perez Elias, M. Jesus; Imaz, Arkaitz; Masià Canuto, Mar; Pérez Álvarez, Nuria; Burgos, Joaquin; Clotet Sala, Bonaventura (2016-04)
    Article
    Accés restringit per política de l'editorial
    Extensively pretreated subjects with virological failure (VF) may receive salvage regimens containing NRTIs with only residual or no activity. Once virological suppression is achieved, their contribution remains elusive. ...
  • Clinical trial designs using CompARE. An on-line exploratory tool for investigators 

    Gómez Mateu, Moisés; Gómez Melis, Guadalupe (2017-03)
    Report de recerca
    Accés obert
    Conclusions from randomized clinical trials (RCT) rely primarily on the primary endpoint (PE) chosen at the design stage of the study. There should generally be only one PE which should be able to provide the most clinically ...
  • In vivo, non-invasive characterization of human bone by hybrid broadband (600-1200 nm) diffuse optical and correlation spectroscopies 

    Konugolu Venkata Sekar, Sanathana; Pagliazzi, Marco; Negredo Puigmal, Eugènia; Martelli, Fabrizio; Farina, Andrea; Dalla Mora, Alberto; Lindner, Claus; Farzam, Parisa; Pérez Álvarez, Nuria; Puig, Jordi; Taroni, Paola; Pifferi, Antonio; Durduran, Turgut (2016-12-20)
    Article
    Accés obert
    Non-invasive in vivo diffuse optical characterization of human bone opens a new possibility of diagnosing bone related pathologies. We present an in vivo characterization performed on seventeen healthy subjects at six ...
  • Safety and efficacy of thrombectomy in acute ischaemic stroke (REVASCAT): 1-year follow-up of a randomised open-label trial 

    Dávalos Errando, Antoni; Cobo Valeri, Erik; Molina, Carlos A.; Chamorro, Ángel; de Miquel, Maria Angeles; San Román, L.; Serena Leal, Joaquín; López-Cancio, Elena; Ribó, Marc; Millán, Mónica; Urra, Xabier; Cardona, Pere; Tomasello, Alejandro; Castaño, Carlos; Blasco, Jordi; Aja, Lucia; Rublera, Marta; Gomis Cortina, Meritxell; Renú, Arturo; Lara, Blanca; Fàbregas, Joan Martí; Jankowitz, Brian; Cerdà, Neus; Jovin, Tudor G. (2017-03-16)
    Article
    Accés restringit per política de l'editorial
  • Bayesian joint ordinal and survival modeling for breast cancer risk assessment 

    Armero, Carmen; Forné, Carles; Rué, Montserrat; Forte Deltell, Anabel; Perpiñán Fabuel, Hèctor; Gómez Melis, Guadalupe; Bare Mañas, Maris (2016-12-10)
    Article
    Accés obert
    We propose a joint model to analyze the structure and intensity of the association between longitudinal measurements of an ordinal marker and time to a relevant event. The longitudinal process is defined in terms of a ...

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