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dc.contributor.authorde Sola Llopis, Susana
dc.contributor.authorDe la Torre Fornell, Rafael
dc.contributor.authorSánchez Benavides, Gonzalo
dc.contributor.authorBenejam, Bessy
dc.contributor.authorCuenca, Aída
dc.contributor.authordel Hoyo, Laura
dc.contributor.authorRodríguez, Joan
dc.contributor.authorCatuara-Solarz, Silvina
dc.contributor.authorSánchez-Gutiérrez, Judit
dc.contributor.authorDueñas-Espín, Ivan
dc.contributor.authorHernández, Gimena
dc.contributor.authorPeña-Casanovas, Jordi
dc.contributor.authorLangohr, Klaus
dc.contributor.authorVidela, Sebastià
dc.contributor.authorBlehaut, Henri
dc.contributor.authorFarré, Magí
dc.contributor.authorDierssen, Mara
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa
dc.date.accessioned2015-10-29T13:43:12Z
dc.date.available2015-10-29T13:43:12Z
dc.date.issued2015-06-04
dc.identifier.citationde Sola, S., De la Torre, R., Sánchez Benavides, G., Benejam, B., Cuenca, A., del Hoyo, L., Rodríguez, J., Catuara-Solarz, S., Sánchez-Gutiérrez, J., Dueñas-Espín, I., Hernández, G., Peña-Casanovas, J., Langohr, K., Videla, S., Blehaut, H., Farré, M., Dierssen, M. A new cognitive evaluation battery for Down syndrome and its relevance for clinical trials. "Frontiers in Psychology", 04 Juny 2015, vol. 6, p. 1-14.
dc.identifier.issn1664-1078
dc.identifier.urihttp://hdl.handle.net/2117/78506
dc.description.abstractThe recent prospect of pharmaceutical interventions for cognitive impairment of Down syndrome (DS) has boosted a number of clinical trials in this population. However, running the trials has raised some methodological challenges and questioned the prevailing methodology used to evaluate cognitive functioning of DS individuals. This is usually achieved by comparing DS individuals to matched healthy controls of the same mental age. We propose a new tool, the TESDAD Battery that uses comparison with age matched typically developed adults. This is an advantageous method for probing the clinical efficacy of DS therapies, allowing the interpretation and prediction of functional outcomes in clinical trials. In our DS population the TESDAD battery permitted a quantitative assessment of cognitive defects, which indicated language dysfunction and deficits in executive function, as the most important contributors to other cognitive and adaptive behavior outcomes as predictors of functional change in DS. Concretely, auditory comprehension and functional academics showed the highest potential as end-point measures of therapeutic intervention for clinical trials: the former as a cognitive key target for therapeutic intervention, and the latter as a primary functional outcome measure of clinical efficacy. Our results also emphasize the need to explore the modulating effects of 10, gender and age on cognitive enhancing treatments. Noticeably, women performed significantly better than men of the same age and IQ in most cognitive tests, with the most consistent differences occurring in memory and executive functioning and negative trends rarely emerged on quality of life linked to the effect of age after adjusting for IQ and gender. In sum, the TESDAD battery is a useful neurocognitive tool for probing the clinical efficacy of experimental therapies in interventional studies in the DS population suggesting that age-matched controls are advantageous for determining normalization of DS.
dc.format.extent14 p.
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències
dc.subject.lcshBiomathematics
dc.subject.otherDown syndrome
dc.subject.otherTESDAD neurocognitive battery
dc.subject.otherintellectual disabilities
dc.subject.othercognition
dc.subject.otherclinical trials as topic
dc.subject.otherVOXEL-BASED MORPHOMETRY
dc.subject.otherQUALITY-OF-LIFE
dc.subject.otherALZHEIMERS-DISEASE
dc.subject.otherNONDEMENTED ADULTS
dc.subject.otherEXECUTIVE FUNCTION
dc.subject.otherGENDER-DIFFERENCES
dc.subject.otherWILLIAMS-SYNDROME
dc.subject.otherWORKING-MEMORY
dc.subject.otherYOUNG-ADULTS
dc.subject.otherDYSFUNCTION
dc.titleA new cognitive evaluation battery for Down syndrome and its relevance for clinical trials
dc.typeArticle
dc.subject.lemacBiologia -- Models matemàtics
dc.contributor.groupUniversitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica
dc.identifier.doi10.3389/fpsyg.2015.00708
dc.description.peerreviewedPeer Reviewed
dc.subject.amsClassificació AMS::92 Biology and other natural sciences::92C Physiological, cellular and medical topics
dc.relation.publisherversionhttp://journal.frontiersin.org/article/10.3389/fpsyg.2015.00708/full
dc.rights.accessOpen Access
local.identifier.drac16652737
dc.description.versionPostprint (author’s final draft)
local.citation.authorde Sola, S.; De la Torre, R.; Sánchez Benavides, G.; Benejam, B.; Cuenca, A.; del Hoyo, L.; Rodríguez, J.; Catuara-Solarz, S.; Sánchez-Gutiérrez, J.; Dueñas-Espín, I.; Hernández, G.; Peña-Casanovas, J.; Langohr, K.; Videla, S.; Blehaut, H.; Farré, M.; Dierssen, M.
local.citation.publicationNameFrontiers in Psychology
local.citation.volume6
local.citation.startingPage1
local.citation.endingPage14


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