Exploratory visualization of misclassified GPCRs from their transformed unaligned sequences using manifold learning techniques
Visualitza/Obre
Estadístiques de LA Referencia / Recolecta
Inclou dades d'ús des de 2022
Cita com:
hdl:2117/78467
Tipus de documentText en actes de congrés
Data publicació2014
EditorCopicentro Granada
Condicions d'accésAccés obert
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Abstract
Class C G-protein-coupled receptors (GPCRs) are cell membrane proteins of great relevance to biology and pharmacology. Previous
research has revealed an upper boundary on the accuracy that can be
achieved in their classification into subtypes from the unaligned transformation of their sequences. To investigate this, we focus on sequences that have been misclassified using supervised methods. These are visualized, using a nonlinear dimensionality reduction technique and phylogenetic trees, and then characterized against the rest of the data and, particularly, against the rest of cases of their own subtype. This should help to discriminate between different types of misclassification and to build hypotheses about database quality problems and the extent to which GPCR sequence transformations limit subtype discriminability. The reported experiments provide a proof of concept for the proposed method.
CitacióCárdenas, M.I., Vellido, A., König, C., Alquezar, R., Giraldo, J. Exploratory visualization of misclassified GPCRs from their transformed unaligned sequences using manifold learning techniques. A: International Work-Conference on Bioinformatics and Biomedical Engineering. "Proceedings IWBBIO 2014: International Work-Conference on Bioinformatics and Biomedical Engineering, Granada April, 7-9 2014". Granada: Copicentro Granada, 2014, p. 623-630.
ISBN978-84-15814-84-9
Fitxers | Descripció | Mida | Format | Visualitza |
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IWBBIO_2014_paper_69.pdf | Article IWBBIO'2014, 623-630 | 746,6Kb | Visualitza/Obre |