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dc.contributor.authorMuñoz Romero, José
dc.contributor.authorGupta, Makund
dc.contributor.authorLadux, Benoit
dc.contributor.authorTrepat Guixer, Xavier
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Matemàtica Aplicada III
dc.date.accessioned2015-10-19T11:41:27Z
dc.date.available2015-10-19T11:41:27Z
dc.date.created2014-09-01
dc.date.issued2014-09-01
dc.identifier.citationMuñoz, J.J., Gupta, M., Ladux, B., Trepat, X. Forces driving epithelial wound healing. "Nature physics", 01 Setembre 2014, vol. 10, núm. 9, p. 683-690.
dc.identifier.issn1745-2473
dc.identifier.urihttp://hdl.handle.net/2117/77874
dc.description.abstractA fundamental feature of multicellular organisms is their ability to self-repair wounds through the movement of epithelial cells into the damaged area. This collective cellular movement is commonly attributed to a combination of cell crawling and 'purse-string' contraction of a supracellular actomyosin ring. Here we show by direct experimental measurement that these two mechanisms are insufficient to explain force patterns observed during wound closure. At early stages of the process, leading actin protrusions generate traction forces that point away from the wound, showing that wound closure is initially driven by cell crawling. At later stages, we observed unanticipated patterns of traction forces pointing towards the wound. Such patterns have strong force components that are both radial and tangential to the wound. We show that these force components arise from tensions transmitted by a heterogeneous actomyosin ring to the underlying substrate through focal adhesions. The structural and mechanical organization reported here provides cells with a mechanism to close the wound by cooperatively compressing the underlying substrate.
dc.format.extent8 p.
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria biomèdica
dc.subject.lcshBiomedical engineering
dc.titleForces driving epithelial wound healing
dc.typeArticle
dc.subject.lemacEnginyeria biomèdica
dc.contributor.groupUniversitat Politècnica de Catalunya. LACÀN - Mètodes Numèrics en Ciències Aplicades i Enginyeria
dc.identifier.doi10.1038/NPHYS3040
dc.relation.publisherversionhttp://www.nature.com/nphys/journal/v10/n9/full/nphys3040.html#author-information
dc.rights.accessOpen Access
local.identifier.drac15229605
dc.description.versionPreprint
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/FP7/242993/EU/Physical Forces Driving Collective Cell Migration: from Genes to Mechanism/GENESFORCEMOTION
local.citation.authorMuñoz, J.J.; Gupta, M.; Ladux, B.; Trepat, X.
local.citation.publicationNameNature physics
local.citation.volume10
local.citation.number9
local.citation.startingPage683
local.citation.endingPage690


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