Biological convergence of cancer signatures
Visualitza/Obre
10.1371/journal.pone.0004544
Inclou dades d'ús des de 2022
Cita com:
hdl:2117/6540
Tipus de documentArticle
Data publicació2009-09-18
Condicions d'accésAccés obert
Llevat que s'hi indiqui el contrari, els
continguts d'aquesta obra estan subjectes a la llicència de Creative Commons
:
Reconeixement-NoComercial-SenseObraDerivada 3.0 Espanya
Abstract
Gene expression profiling has identified cancer prognostic and predictive signatures with superior performance to
conventional histopathological or clinical parameters. Consequently, signatures are being incorporated into clinical practice
and will soon influence everyday decisions in oncology. However, the slight overlap in the gene identity between signatures
for the same cancer type or condition raises questions about their biological and clinical implications. To clarify these issues,
better understanding of the molecular properties and possible interactions underlying apparently dissimilar signatures is
needed. Here, we evaluated whether the signatures of 24 independent studies are related at the genome, transcriptome or
proteome levels. Significant associations were consistently observed across these molecular layers, which suggest the
existence of a common cancer cell phenotype. Convergence on cell proliferation and death supports the pivotal
involvement of these processes in prognosis, metastasis and treatment response. In addition, functional and molecular
associations were identified with the immune response in different cancer types and conditions that complement the
contribution of cell proliferation and death. Examination of additional, independent, cancer datasets corroborated our
observations. This study proposes a comprehensive strategy for interpreting cancer signatures that reveals common design
principles and systems-level properties.
CitacióSolé, X. [et al.]. Biological convergence of cancer signatures. "PLOS one", 18 Setembre 2009, vol. 4, núm. 2.
ISSN1932-6203
Fitxers | Descripció | Mida | Format | Visualitza |
---|---|---|---|---|
francesc comellas.pdf | Artículo principal | 1,261Mb | Visualitza/Obre |