Enviaments recents

  • Effect of solvent choice on the self-assembly properties of a diphenylalanine amphiphile stabilized by an ion pair 

    Mayans Tayadella, Enric; Ballano Ballano, María Gema; Sendros, Javier; Font Bardia, Mercè; Campos López, Josefina de Lourdes; Puiggalí Bellalta, Jordi; Cativiela, Carlos; Alemán Llansó, Carlos (2017-07-19)
    Article
    Accés restringit per política de l'editorial
    A diphenylalanine (FF) amphiphile blocked at the C terminus with a benzyl ester (OBzl) and stabilized at the N terminus with a trifluoroacetate (TFA) anion was synthetized and characterized. Aggregation of peptide molecules ...
  • Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast 

    Millán Elías, Cinthia Raquel; Acosta Reyes, Francisco Javier; Lagartera, Laura; Ebiloma, Godwin U.; Lemgruber, Leandro; Nué Martinez, J. Jonathan; Saperas Plana, Núria; Dardonville, Cristophe; De Koning, Harry Pieter; Campos López, Josefina de Lourdes (2017-08-21)
    Article
    Accés obert
    Trypanosoma brucei, the causative agent of sleeping sickness (Human African Trypanosomiasis, HAT), contains a kinetoplast with the mitochondrial DNA (kDNA), comprising of >70% AT base pairs. This has prompted studies of ...
  • Paternal contribution to development: sperm genetic damage and repair in fish 

    Herráez, María Paz; Ausió, Juan; Devaux, Alain; González-Rojo, Silvia; Fernández-Díez, Cristina; Bony, Sylvie; Saperas Plana, Núria; Robles, Vanesa (2017-04-01)
    Article
    Accés obert
    In this review we provide an overview of the components of the spermatozoa playing an important role in reproductive success beyond fertilization, showing the relationship between the integrity of the diverse elements and ...
  • Crystalline structure and thermotropic behavior of alkyltrimethylphosphonium amphiphiles 

    Gamarra Montes, Ana; Urpí Garriga, Lourdes; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Muñoz Guerra, Sebastián (2017-02-14)
    Article
    Accés restringit per política de l'editorial
    Quaternary organophosphonium salts bearing long alkyl chains are cationic surfactants of interest owing to their physical and biological properties. In the present work, the crystal structure and thermotropic behavior of ...
  • Intercalative DNA binding of the marine anticancer drug variolin B 

    Canals, Albert; Arribas Bosacoma, Raquel; Albericio Palomera, Fernando; Alvarez Domingo, Mercedes; Aymami Bofarull, Juan; Coll, Miquel (Macmillan Publishers, 2017-01-04)
    Article
    Accés obert
    Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic ...
  • Paternal contribution to development: Spermgenetic damage and repair in fish 

    Herráez, María Paz; Ausió, Juan; Devaux, Alain; González-Rojo, Silvia; Fernández-Díez, Cristina; Bony, Sylvie; Saperas Plana, Núria; Robles, Vanessa (2016)
    Article
    Accés restringit per política de l'editorial
    In this review we provide an overview of the components of the spermatozoa playing an important role in reproductive success beyond fertilization , showing the relationship between the integrity of the diverse elements and ...
  • Spermiogenesis and biflagellate spermatozoon of the teleost fish Lampanyctus crocodilus (Myctophiformes, Myctophidae): ultrastructure and characterisation of its sperm basic nuclear proteins 

    Ribes, Enric; Cheema, M; Gonzalez Romero, R.; LLORIS, D.; Ausió, Juan; Saperas Plana, Núria (2015-08-01)
    Article
    Accés obert
    We undertook an ultrastructural study of the spermiogenesis of the lanternfish Lampanyctus crocodilus (Myctophiformes, Myctophidae) with special emphasis on the condensation of chromatin and the biochemical characterisation ...
  • High evolutionary turnover of satellite families in Caenorhabditis 

    Subirana Torrent, Juan A.; Albà, M. Mar; Messeguer Peypoch, Xavier (2015-10-05)
    Article
    Accés obert
    Background: The high density of tandem repeat sequences (satellites) in nematode genomes and the availability of genome sequences from several species in the group offer a unique opportunity to better understand the ...
  • Two high-mobility group box domains act together to underwind and kink DNA. 

    Sánchez Giraldo, Raquel; Acosta Reyes, Francisco Javier; Malarkey, Christopher S.; Saperas Plana, Núria; Churchill, Mair E. A.; Campos López, Josefina de Lourdes (2015-07-02)
    Article
    Accés obert
    High-mobility group protein 1 (HMGB1) is an essential and ubiquitous DNA architectural factor that influences a myriad of cellular processes. HMGB1 contains two DNA-binding domains, box A and box B, which have little ...
  • Structure of the DNA duplex d(ATTAAT)(2) with Hoogsteen hydrogen bonds 

    Acosta Reyes, Francisco Javier; Subirana, Juan Antonio; Campos López, Josefina de Lourdes; Alechaga, Elida (2015-03-17)
    Article
    Accés obert
    The traditional Watson-Crick base pairs in DNA may occasionally adopt a Hoogsteen conformation, with a different organization of hydrogen bonds. Previous crystal structures have shown that the Hoogsteen conformation is ...

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