Recent Submissions

  • Randomised study to assess the efficacy and safety of once-daily etravirine-based regimen as a switching strategy in HIV-infected patients receiving a protease inhibitor-containing regimen. Etraswitch study 

    Echeverria, Patricia; Bonjoch, Anna; Puig Batalla, Jorge; Molto, Jose; Paredes, Roger; Sirera, Guillem; Ornelas, Arelly; Pérez Álvarez, Nuria; Clotet, Bonaventura; Negredo, Eugènia (2014-02-04)
    Article
    Open Access
    Background: Etravirine (ETR) was approved for patients with virological failure and antiretroviral resistance mutations. It has also shown antiviral efficacy in antiretroviral-naive patients. However, data on the switching ...
  • On left-truncating and mixing poisson distributions 

    Valero Baya, Jordi; Pérez Casany, Marta; Ginebra Molins, Josep (2014-02-01)
    Article
    Open Access
    The distributions obtained by left-truncating at k a mixed Poisson distribution, kT-MP, and those obtained by mixing previously left-truncated Poisson distributions, M-kTP, are characterized by means of their probability ...
  • Young biostatisticians in Spain: career or race? 

    Lorenzo Arribas, Altea; Martínez Silva, Isabel; Gómez Mateu, Moisés; Pérez Álvarez, Nuria; Perpiñán Fabuel, Hèctor; Valero Coppin, Oliver (Sociedad de Estadística e Investigación Operativa (SEIO), 2013-10)
    Article
    Restricted access - publisher's policy
    Challenges and new opportunities for the integration of biostatisticians in multidisciplinary teams are a major concern in the field. New forms of broader training in the life sciences, collaborations with other scientists, ...
  • Quantile estimation of the rejection distribution of food products integrating assessor values and interval-censored consumer data 

    Langohr, Klaus; Gómez Melis, Guadalupe; Hough, Guillermo (2013-12)
    Article
    Restricted access - publisher's policy
    Fitting parametric survival models with interval-censore d data is a common task in survival analysis and implemented in many statistical software pack ages. Here, we present a novel approach to fit such models if the ...
  • On poisson-stopped-sums that are mixed poisson 

    Valero Baya, Jordi; Pérez Casany, Marta; Ginebra Molins, Josep (2013)
    Article
    Restricted access - publisher's policy
    Maceda (1948) characterized the mixed Poisson distributions that are Poisson-stopped-sum distributions based on the mixing distribution. In an alternative characterization of the same set of distributions here the ...
  • Time of progression to osteopenia/osteoporosis in chronically HIV-infected patients: screening DXA scan 

    Negredo, Eugènia; Bonjoch, Anna; Gómez Mateu, Moisés; Estany, Carla; Puig, Jordi; Pérez Álvarez, Nuria; Rosales, Joaquim; di Gregorio, Silvana; del Rio, Luis; Gómez Melis, Guadalupe; Clotet, Bonaventura (2012-10-08)
    Article
    Open Access
    Algorithms for bone mineral density (BMD) management in HIV-infected patients are lacking. Our objective was to assess how often a dual-energy x-ray absorptiometry (DXA) scan should be performed by assessing time of ...
  • BioStatNet: an interdisciplinary biostatistics network 

    Bayarri García, María Jesús; Cadarso Suárez, Carmen; Durbán Reguera, María Luz; Gómez Melis, Guadalupe; López Fidalgo, Jesús; Martín Andrés, Antonio; Nuñez Antón, Vicente; Puig Casado, Pere (Sociedad de Estadística e Investigación Operativa (SEIO), 2012-06)
    Article
    Open Access
    Biostatistics has become a major scientific component of biomedical research with a strong interdisciplinary basis. This endeavour is essentially interdisciplinary, therefore, training of future biostatisticians must ...
  • Flexible geoadditive survival analysis of non-Hodgkin lymphoma in Peru 

    Flores, Claudio; Rodríguez-Girondo, Mar; Cadarso Suárez, Carmen; Kneib, Thomas; Gómez Melis, Guadalupe; Casanova, Lluis (2012-06)
    Article
    Open Access
    Knowledge of prognostic factors is an important task for the clinical management of Non Hodgkin Lymphoma (NHL). In this work, we study the variables affecting survival of NHL in Peru by means of geoadditive Cox-type ...
  • Statistical considerations when using a composite endpoint for comparing treatment groups 

    Gómez Melis, Guadalupe; Lagakos, Stephen W. (2012-08)
    Article
    Restricted access - publisher's policy
    When comparing two treatment groups in a time-to-event analysis, it is common to use a composite event consisting of two or more distinct outcomes. The goal of this paper is to develop a statistical methodology to derive ...
  • Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy''): the influence of gender and genetics (CYP2D6, COMT, 5-HTT) 

    Pardo-Lozano, Ricardo; Farré, Magí; Yubero-Lahoz, Samanta; O’Mathúna, Brian; Torrens, M.; Mustata, Cristina; Pérez-Mañá, Clara; Langohr, Klaus; Cuyàs, Elisabet; Carbó, Marcel·lí; de la Torre, Rafael (2012-10-24)
    Article
    Open Access
    The synthetic psychostimulant MDMA (63,4-methylenedioxymethamphetamine, ecstasy) acts as an indirect serotonin, dopamine, and norepinephrine agonist and as a mechanism-based inhibitor of the cytochrome P-450 2D6 (CYP2D6). ...

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