Mostra el registre d'ítem simple
Reducing the n-gram feature space of class C GPCRs to subtype-discriminating patterns
dc.contributor.author | König, Caroline |
dc.contributor.author | Alquézar Mancho, René |
dc.contributor.author | Vellido Alcacena, Alfredo |
dc.contributor.author | Giraldo Arjonilla, Jesús |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Ciències de la Computació |
dc.date.accessioned | 2015-06-19T08:03:26Z |
dc.date.available | 2015-06-19T08:03:26Z |
dc.date.created | 2014-10-23 |
dc.date.issued | 2014-10-23 |
dc.identifier.citation | König, C. [et al.]. Reducing the n-gram feature space of class C GPCRs to subtype-discriminating patterns. "Journal of integrative bioinformatics", 23 Octubre 2014, vol. 11, núm. 3. |
dc.identifier.issn | 1613-4516 |
dc.identifier.uri | http://hdl.handle.net/2117/28347 |
dc.description.abstract | G protein-coupled receptors (GPCRs) are a large and heterogeneous superfamily of receptors that are key cell players for their role as extracellular signal transmitters. Class C GPCRs, in particular, are of great interest in pharmacology. The lack of knowledge about their full 3-D structure prompts the use of their primary amino acid sequences for the construction of robust classifiers, capable of discriminating their different subtypes. In this paper, we investigate the use of feature selection techniques to build Support Vector Machine (SVM)-based classification models from selected receptor subsequences described as n-grams. We show that this approach to classification is useful for finding class C GPCR subtype-specific motifs. |
dc.format.extent | 17 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Informàtica::Intel·ligència artificial |
dc.subject | Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica |
dc.subject.lcsh | Protein research |
dc.subject.other | G protein-coupled receptors |
dc.subject.other | GPCRs |
dc.subject.other | Support vector machine-based classification |
dc.subject.other | SVM-based classification |
dc.title | Reducing the n-gram feature space of class C GPCRs to subtype-discriminating patterns |
dc.type | Article |
dc.subject.lemac | Proteïnes -- Investigació |
dc.contributor.group | Universitat Politècnica de Catalunya. VIS - Visió Artificial i Sistemes Intel·ligents |
dc.contributor.group | Universitat Politècnica de Catalunya. SOCO - Soft Computing |
dc.identifier.doi | 10.2390/biecoll-jib-2014-254 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://journal.imbio.de/article.php?aid=254 |
dc.rights.access | Open Access |
local.identifier.drac | 16495527 |
dc.description.version | Postprint (published version) |
local.citation.author | König, C.; Alquezar, R.; Vellido, A.; Giraldo, J. |
local.citation.publicationName | Journal of integrative bioinformatics |
local.citation.volume | 11 |
local.citation.number | 3 |
local.citation.startingPage | Paper 254 |
Fitxers d'aquest items
Aquest ítem apareix a les col·leccions següents
-
Articles de revista [1.049]
-
Articles de revista [66]
-
Articles de revista [140]