Validation of a portable device for mapping motor and gait disturbances in Parkinson’s disease
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Tipus de documentArticle
Data publicació2015-02-02
EditorJMIR
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Abstract
Background: Patients with severe idiopathic Parkinson’s disease experience motor fluctuations, which are often difficult to
control. Accurate mapping of such motor fluctuations could help improve patients’ treatment.
Objective: The objective of the study was to focus on developing and validating an automatic detector of motor fluctuations.
The device is small, wearable, and detects the motor phase while the patients walk in their daily activities.
Methods: Algorithms for detection of motor fluctuations were developed on the basis of experimental data from 20 patients
who were asked to wear the detector while performing different daily life activities, both in controlled (laboratory) and noncontrolled
environments. Patients with motor fluctuations completed the experimental protocol twice: (1) once in the ON, and (2) once in
the OFF phase. The validity of the algorithms was tested on 15 different patients who were asked to wear the detector for several
hours while performing daily activities in their habitual environments. In order to assess the validity of detector measurements,
the results of the algorithms were compared with data collected by trained observers who were accompanying the patients all the
time.
Results: The motor fluctuation detector showed a mean sensitivity of 0.96 (median 1; interquartile range, IQR, 0.93-1) and
specificity of 0.94 (median 0.96; IQR, 0.90-1).
Conclusions: ON/OFF motor fluctuations in Parkinson's patients can be detected with a single sensor, which can be worn in
everyday life
CitacióRodríguez, A. [et al.]. Validation of a portable device for mapping motor and gait disturbances in Parkinson’s disease. "JMIR mobile and ubiquitous health (mhealth & uhealth)", 02 Febrer 2015, vol. 3, núm. 1.
ISSN2291-5222
Versió de l'editorhttp://mhealth.jmir.org/2015/1/e9/
Fitxers | Descripció | Mida | Format | Visualitza |
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Manuscript_rodriguez_JMIR_R1_3__postprint.pdf | 841,0Kb | Accés restringit |