PublisherInstitute of Electrical and Electronics Engineers (IEEE)
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This brief paper addresses the problem of visually assessing the natural discriminability of the different subtypes that characterize class C G-Protein-Coupled Receptors, which are membrane proteins of interest in pharmacology, from diverse transformations of their primary amino acid sequences. Visualization, achieved using nonlinear dimensionality reduction techniques, is used as an exploratory tool to increase the interpretability of the data subtype structure. Combined with a quantitative estimation of subtype overlapping, this approach should be of help to experts in proteomics.
CitationCárdenas, M.I.; Vellido, A.; Giraldo, J. Visual interpretation of class C GPCR subtype overlapping from the nonlinear mapping of transformed primary sequences. A: IEEE-EMBS International Conferences on Biomedical and Health Informatics. "2014 IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI 2014)". Valencia: Institute of Electrical and Electronics Engineers (IEEE), 2014, p. 764-767.
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