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dc.contributor.authorRadszuweit, M.
dc.contributor.authorÁlvarez Lacalle, Enrique
dc.contributor.authorBär, Markus
dc.contributor.authorEchebarría Domínguez, Blas
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Física Aplicada
dc.date.accessioned2015-06-01T11:01:10Z
dc.date.available2015-06-01T11:01:10Z
dc.date.created2015-02-04
dc.date.issued2015-02-04
dc.identifier.citationRadszuweit, M. [et al.]. Cardiac contraction induces discordant alternans and localized block. "Physical review E: statistical, nonlinear, and soft matter physics", 04 Febrer 2015, vol. 91, núm. 2.
dc.identifier.issn1539-3755
dc.identifier.urihttp://hdl.handle.net/2117/28119
dc.description.abstractIn this paper we use a simplified model of cardiac excitation-contraction coupling to study the effect of tissue deformation on the dynamics of alternans, i.e., alternations in the duration of the cardiac action potential, that occur at fast pacing rates and are known to be proarrhythmic. We show that small stretch-activated currents can produce large effects and cause a transition from in-phase to off-phase alternations (i.e., from concordant to discordant alternans) and to conduction blocks. We demonstrate numerically and analytically that this effect is the result of a generic change in the slope of the conduction velocity restitution curve due to electromechanical coupling. Thus, excitation-contraction coupling can potentially play a relevant role in the transition to reentry and fibrillation.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Ciències de la salut
dc.subject.lcshHeart--Electric properties
dc.subject.lcshHeart--Mechanical properties
dc.subject.otherSTRETCH-INDUCED CHANGES
dc.subject.otherT-WAVE
dc.subject.otherMECHANOELECTRIC FEEDBACK
dc.subject.otherELECTRICAL ALTERNANS
dc.subject.otherEXCITABLE MEDIA
dc.subject.otherSPIRAL WAVES
dc.subject.otherMECHANISMS
dc.subject.otherTISSUE
dc.subject.otherVULNERABILITY
dc.subject.otherFIBRILLATION
dc.titleCardiac contraction induces discordant alternans and localized block
dc.typeArticle
dc.contributor.groupUniversitat Politècnica de Catalunya. BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos
dc.identifier.doi10.1103/PhysRevE.91.022703
dc.description.peerreviewedPeer Reviewed
dc.rights.accessOpen Access
local.identifier.drac15504655
dc.description.versionPostprint (published version)
local.citation.authorRadszuweit, M.; Alvarez-Lacalle, E.; Bär, M.; Echebarria, B.
local.citation.publicationNamePhysical review E: statistical, nonlinear, and soft matter physics
local.citation.volume91
local.citation.number2


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