Mostra el registre d'ítem simple
Cardiac contraction induces discordant alternans and localized block
dc.contributor.author | Radszuweit, M. |
dc.contributor.author | Álvarez Lacalle, Enrique |
dc.contributor.author | Bär, Markus |
dc.contributor.author | Echebarría Domínguez, Blas |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Física Aplicada |
dc.date.accessioned | 2015-06-01T11:01:10Z |
dc.date.available | 2015-06-01T11:01:10Z |
dc.date.created | 2015-02-04 |
dc.date.issued | 2015-02-04 |
dc.identifier.citation | Radszuweit, M. [et al.]. Cardiac contraction induces discordant alternans and localized block. "Physical review E: statistical, nonlinear, and soft matter physics", 04 Febrer 2015, vol. 91, núm. 2. |
dc.identifier.issn | 1539-3755 |
dc.identifier.uri | http://hdl.handle.net/2117/28119 |
dc.description.abstract | In this paper we use a simplified model of cardiac excitation-contraction coupling to study the effect of tissue deformation on the dynamics of alternans, i.e., alternations in the duration of the cardiac action potential, that occur at fast pacing rates and are known to be proarrhythmic. We show that small stretch-activated currents can produce large effects and cause a transition from in-phase to off-phase alternations (i.e., from concordant to discordant alternans) and to conduction blocks. We demonstrate numerically and analytically that this effect is the result of a generic change in the slope of the conduction velocity restitution curve due to electromechanical coupling. Thus, excitation-contraction coupling can potentially play a relevant role in the transition to reentry and fibrillation. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Ciències de la salut |
dc.subject.lcsh | Heart--Electric properties |
dc.subject.lcsh | Heart--Mechanical properties |
dc.subject.other | STRETCH-INDUCED CHANGES |
dc.subject.other | T-WAVE |
dc.subject.other | MECHANOELECTRIC FEEDBACK |
dc.subject.other | ELECTRICAL ALTERNANS |
dc.subject.other | EXCITABLE MEDIA |
dc.subject.other | SPIRAL WAVES |
dc.subject.other | MECHANISMS |
dc.subject.other | TISSUE |
dc.subject.other | VULNERABILITY |
dc.subject.other | FIBRILLATION |
dc.title | Cardiac contraction induces discordant alternans and localized block |
dc.type | Article |
dc.contributor.group | Universitat Politècnica de Catalunya. BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos |
dc.identifier.doi | 10.1103/PhysRevE.91.022703 |
dc.description.peerreviewed | Peer Reviewed |
dc.rights.access | Open Access |
local.identifier.drac | 15504655 |
dc.description.version | Postprint (published version) |
local.citation.author | Radszuweit, M.; Alvarez-Lacalle, E.; Bär, M.; Echebarria, B. |
local.citation.publicationName | Physical review E: statistical, nonlinear, and soft matter physics |
local.citation.volume | 91 |
local.citation.number | 2 |
Fitxers d'aquest items
Aquest ítem apareix a les col·leccions següents
-
Articles de revista [220]
-
Articles de revista [454]