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Design considerations for a CMOS Lab-on-Chip microheater array to facilitate the in vitro thermal stimulation of neurons
dc.contributor.author | Reverter Cubarsí, Ferran |
dc.contributor.author | Prodromakis, Themis |
dc.contributor.author | Liu, Yan |
dc.contributor.author | Georgiou, Pantelis |
dc.contributor.author | Nikolic, Konstantin |
dc.contributor.author | Constandinou, Tim |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica |
dc.date.accessioned | 2015-04-14T14:06:34Z |
dc.date.created | 2014 |
dc.date.issued | 2014 |
dc.identifier.citation | Reverter, F. [et al.]. Design considerations for a CMOS Lab-on-Chip microheater array to facilitate the in vitro thermal stimulation of neurons. A: IEEE International Symposium on Circuits and Systems. "2014 IEEE International Symposium on Circuits and Systems (ISCAS 2014): Melbourne, Australia: 1-5 June 2014". Melbourne: Institute of Electrical and Electronics Engineers (IEEE), 2014, p. 630-633. |
dc.identifier.isbn | 978-1-4799-3433-1 |
dc.identifier.uri | http://hdl.handle.net/2117/27324 |
dc.description.abstract | This paper identifies and addresses key design considerations and trade-offs in the implementation of a CMOS high-resolution microheater array for Lab-on-Chip (LOC) applications. Specifically, this is investigated in the context of facilitating the in vitro thermal stimulation of single neurons. The paper analyses the electro-thermal response (by means of COMSOL simulations) and reliability issues (such as melting and electromigration) of different microheater designs. The analysis shows that a small-area heater is more efficient in terms of power, but it has more reliability problems essentially due to electromigration effects. For the proposed heater designs, the expected lifetime is a few days (in continuous operation) in the worst scenario, which is still generally acceptable for LOC applications. |
dc.format.extent | 4 p. |
dc.language.iso | eng |
dc.publisher | Institute of Electrical and Electronics Engineers (IEEE) |
dc.subject | Àrees temàtiques de la UPC::Física::Electromagnetisme |
dc.subject | Àrees temàtiques de la UPC::Enginyeria electrònica::Electrònica de potència |
dc.subject.lcsh | Electromagnetism |
dc.subject.lcsh | Electronic circuits |
dc.subject.other | lab-on-chip |
dc.subject.other | heater |
dc.subject.other | neurons |
dc.subject.other | thermal stimulation |
dc.title | Design considerations for a CMOS Lab-on-Chip microheater array to facilitate the in vitro thermal stimulation of neurons |
dc.type | Conference report |
dc.subject.lemac | Circuits electronics |
dc.contributor.group | Universitat Politècnica de Catalunya. e-CAT - Circuits i Transductors Electrònics |
dc.identifier.doi | 10.1109/ISCAS.2014.6865214 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=6865214&tag=1 |
dc.rights.access | Restricted access - publisher's policy |
local.identifier.drac | 15205876 |
dc.description.version | Postprint (published version) |
dc.date.lift | 10000-01-01 |
local.citation.author | Reverter, F.; Prodromakis, T.; Liu, Y.; Georgiou, P.; Nikolic, K.; Constandinou, T. |
local.citation.contributor | IEEE International Symposium on Circuits and Systems |
local.citation.pubplace | Melbourne |
local.citation.publicationName | 2014 IEEE International Symposium on Circuits and Systems (ISCAS 2014): Melbourne, Australia: 1-5 June 2014 |
local.citation.startingPage | 630 |
local.citation.endingPage | 633 |