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Poly(ß,L-malic acid)/Doxorubicin ionic complex: A pH-dependent delivery system
| dc.contributor.author | Lanz Landazuri, Alberto |
| dc.contributor.author | Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon |
| dc.contributor.author | García Álvarez, Montserrat |
| dc.contributor.author | Muñoz Guerra, Sebastián |
| dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química |
| dc.date.accessioned | 2014-05-21T09:44:16Z |
| dc.date.created | 2014-08-01 |
| dc.date.issued | 2014-08-01 |
| dc.identifier.citation | Lanz, A. [et al.]. Poly(ß,L-malic acid)/Doxorubicin ionic complex: A pH-dependent delivery system. "Reactive and functional polymers", 01 Agost 2014, vol. 81, p. 45-53. |
| dc.identifier.issn | 1381-5148 |
| dc.identifier.uri | http://hdl.handle.net/2117/23027 |
| dc.description.abstract | Poly(beta,L-malic acid) (PMLA) was made to interact with the cationic anticancer drug Doxorubicin (DOX) in aqueous solution to form ionic complexes with different compositions and an efficiency near to 100%. The PMLA/DOX complexes were characterized by spectroscopy, thermal analysis, and scanning electron microscopy. According to their composition, the PMLA/DOX complexes spontaneously self-assembled into spherical micro or nanoparticles with negative surface charge. Hydrolytic degradation of PMLA/ DOX complexes took place by cleavage of the main chain ester bond and simultaneous release of the drug. In vitro drug release studies revealed that DOX delivery from the complexes was favored by acidic pH and high ionic strength. |
| dc.format.extent | 9 p. |
| dc.language.iso | eng |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
| dc.subject | Àrees temàtiques de la UPC::Enginyeria química |
| dc.subject.lcsh | Polymers |
| dc.subject.other | Poly(malic acid) |
| dc.subject.other | Ionic complexes |
| dc.subject.other | Doxorubicin complex |
| dc.subject.other | pH-dependent |
| dc.subject.other | Drug-delivery particle |
| dc.title | Poly(ß,L-malic acid)/Doxorubicin ionic complex: A pH-dependent delivery system |
| dc.type | Article |
| dc.subject.lemac | Polímers |
| dc.contributor.group | Universitat Politècnica de Catalunya. POL - Polímers Industrials Avançats i Biopolímers Tecnològics |
| dc.identifier.doi | 10.1016/j.reactfunctpolym.2014.04.005 |
| dc.description.peerreviewed | Peer Reviewed |
| dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S1381514814000959 |
| dc.rights.access | Restricted access - publisher's policy |
| local.identifier.drac | 14891642 |
| dc.description.version | Postprint (published version) |
| dc.date.lift | 10000-01-01 |
| local.citation.author | Lanz, A.; Martinez de Ilarduya, A.; Garcia, M.; Muñoz, S. |
| local.citation.publicationName | Reactive and functional polymers |
| local.citation.volume | 81 |
| local.citation.startingPage | 45 |
| local.citation.endingPage | 53 |
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