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Poly(beta,L-malic acid) (PMLA) was made to interact with the cationic anticancer drug Doxorubicin (DOX) in
aqueous solution to form ionic complexes with different compositions and an efficiency near to 100%. The
PMLA/DOX complexes were characterized by spectroscopy, thermal analysis, and scanning electron
microscopy. According to their composition, the PMLA/DOX complexes spontaneously self-assembled
into spherical micro or nanoparticles with negative surface charge. Hydrolytic degradation of PMLA/
DOX complexes took place by cleavage of the main chain ester bond and simultaneous release of the
drug. In vitro drug release studies revealed that DOX delivery from the complexes was favored by acidic
pH and high ionic strength.
CitacióLanz, A. [et al.]. Poly(ß,L-malic acid)/Doxorubicin ionic complex: A pH-dependent delivery system. "Reactive and functional polymers", 01 Agost 2014, vol. 81, p. 45-53.