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Conformational control of integrin subtype selectivity in isoDGR peptide motifs: A biological switch

dc.contributor.authorFrank, A.O.
dc.contributor.authorOtto, E.
dc.contributor.authorMas Moruno, Carlos
dc.contributor.authorSchiller, H.
dc.contributor.authorMarinelli, L.
dc.contributor.authorCosconati, S.
dc.contributor.authorBochen, A.
dc.contributor.authorVossmeyer, D.
dc.contributor.authorZahn, G.
dc.contributor.authorStragies, R.
dc.contributor.authorNovellino, E.
dc.contributor.authorKessler, H.
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2014-05-05T07:54:34Z
dc.date.created2010
dc.date.issued2010
dc.identifier.citationFrank, A.O. [et al.]. Conformational control of integrin subtype selectivity in isoDGR peptide motifs: A biological switch. "Angewandte chemie. International edition", 2010, vol. 49, núm. 48, p. 9278-9281.
dc.identifier.issn1433-7851
dc.identifier.urihttp://hdl.handle.net/2117/22807
dc.description.abstractThumbnail image of graphical abstract The rearrangement of asparagine to isoaspartate (isoD) is responsible for the deactivation of many functional proteins. However, the isoDGR motif, which is optimally presented as a conformationally controlled cyclic pentapeptide, binds selectively to a5ß1 integrin (see the docking model) with an affinity comparable to that of the peptidic antitumor agent Cilengitide
dc.format.extent4 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshPeptides
dc.subject.othercyclic pentapeptides
dc.subject.otherintegrin ligands
dc.subject.otherisoDGR sequence
dc.subject.otherNMR spectroscopy
dc.subject.otherpeptides
dc.titleConformational control of integrin subtype selectivity in isoDGR peptide motifs: A biological switch
dc.typeArticle
dc.subject.lemacPèptids
dc.identifier.doi10.1002/anie.201004363
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1002/anie.201004363/abstract
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac13620329
dc.description.versionPostprint (published version)
dc.date.lift10000-01-01
local.citation.authorFrank, A.O.; Otto, E.; Mas-Moruno, C.; Schiller, H.; Marinelli, L.; Cosconati, S.; Bochen, A.; Vossmeyer, D.; Zahn, G.; Stragies, R.; Novellino, E.; Kessler, H.
local.citation.publicationNameAngewandte chemie. International edition
local.citation.volume49
local.citation.number48
local.citation.startingPage9278
local.citation.endingPage9281


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