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Neurogenesis and vascularization of the damaged brain using a lactate-releasing biomimetic scaffold
dc.contributor.author | Álvarez Pinto, Zaída |
dc.contributor.author | Castaño Linares, Óscar |
dc.contributor.author | Castells, Alba |
dc.contributor.author | Mateos Timoneda, Miguel Ángel |
dc.contributor.author | Planell Estany, Josep Anton |
dc.contributor.author | Engel López, Elisabeth |
dc.contributor.author | Alcántara, Soledad |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica |
dc.contributor.other | Institut de Bioenginyeria de Catalunya |
dc.date.accessioned | 2014-04-23T09:46:23Z |
dc.date.created | 2014-06 |
dc.date.issued | 2014-06 |
dc.identifier.citation | Álvarez, Z. [et al.]. Neurogenesis and vascularization of the damaged brain using a lactate-releasing biomimetic scaffold. "Biomaterials", Juny 2014, vol. 35, núm. 17, p. 4769-4781. |
dc.identifier.issn | 0142-9612 |
dc.identifier.uri | http://hdl.handle.net/2117/22661 |
dc.description.abstract | Regenerative medicine strategies to promote recovery following traumatic brain injuries are currently focused on the use of biomaterials as delivery systems for cells or bioactive molecules. This study shows that cell-free biomimetic scaffolds consisting of radially aligned electrospun poly-l/dl lactic acid (PLA70/30) nanofibers release l-lactate and reproduce the 3D organization and supportive function of radial glia embryonic neural stem cells. The topology of PLA nanofibers supports neuronal migration while l-lactate released during PLA degradation acts as an alternative fuel for neurons and is required for progenitor maintenance. Radial scaffolds implanted into cavities made in the postnatal mouse brain fostered complete implant vascularization, sustained neurogenesis, and allowed the long-term survival and integration of the newly generated neurons. Our results suggest that the endogenous central nervous system is capable of regeneration through the invivo dedifferentiation induced by biophysical and metabolic cues, with no need for exogenous cells, growth factors, or genetic manipulation. |
dc.format.extent | 13 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials |
dc.subject.lcsh | Regenerative medicine--Materials |
dc.subject.lcsh | Neurogenesis |
dc.subject.other | Lactate |
dc.subject.other | Nanofibers |
dc.subject.other | Neural stem cells |
dc.subject.other | Neurogenesis |
dc.subject.other | Regeneration |
dc.subject.other | Vascularization |
dc.title | Neurogenesis and vascularization of the damaged brain using a lactate-releasing biomimetic scaffold |
dc.type | Article |
dc.subject.lemac | Neurogenètica |
dc.subject.lemac | Biomaterials |
dc.contributor.group | Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits |
dc.identifier.doi | 10.1016/j.biomaterials.2014.02.051 |
dc.rights.access | Restricted access - publisher's policy |
local.identifier.drac | 14003364 |
dc.description.version | Postprint (published version) |
dc.date.lift | 10000-01-01 |
local.citation.author | Álvarez, Z.; Castaño, O.; Castells, A.; Mateos, M.; Planell, J.; Engel, E.; Alcantara, S. |
local.citation.publicationName | Biomaterials |
local.citation.volume | 35 |
local.citation.number | 17 |
local.citation.startingPage | 4769 |
local.citation.endingPage | 4781 |
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