Study on the hydrolytic degradation of the segmented GL-b-[GL-co-TMC-co-CL] -b-GL copolymer with application as monofilar surgical suture
Visualitza/Obre
polymer.pdf (3,669Mb) (Accés restringit)
Sol·licita una còpia a l'autor
Què és aquest botó?
Aquest botó permet demanar una còpia d'un document restringit a l'autor. Es mostra quan:
- Disposem del correu electrònic de l'autor
- El document té una mida inferior a 20 Mb
- Es tracta d'un document d'accés restringit per decisió de l'autor o d'un document d'accés restringit per política de l'editorial
Cita com:
hdl:2117/22440
Tipus de documentArticle
Data publicació2013-12
Condicions d'accésAccés restringit per política de l'editorial
Llevat que s'hi indiqui el contrari, els
continguts d'aquesta obra estan subjectes a la llicència de Creative Commons
:
Reconeixement-NoComercial-SenseObraDerivada 3.0 Espanya
Abstract
The hydrolytic degradation of Monosyn™, a segmented copolymer derived from glycolide, trimethylene carbonate and e-caprolactone, has been evaluated in buffered aqueous media at different pH and temperature. Degradation processes have been followed by considering mass loss and molecular weight profiles as well as the changes on 1H NMR and FTIR spectra, morphology and both calorimetric and mechanical properties during exposure to the selected media and temperature. In all cases, the mass and molecular weight evolutions fitted with first order kinetic processes which were indicative of a random chain scission mechanism. Rate constants were found to strongly depend on temperature and pH. A slight deviation towards a backbiting mechanism was only found in the acid medium at long exposure times when degradation progresses through crystalline domains and recombination of ester groups were probable. Amorphous and glycolide rich domains were more susceptible to the hydrolytic attack as revealed from mechanical assays and both spectroscopic and calorimetric data. Morphological changes occurring during degradation were highly dependent on pH and indeed different steps affecting the outer (longitudinal cracks) and inner (transversal cracks) parts of sutures could be distinguished. The high content on amorphous soft segments gave rise to well-defined circumferential cracks that affected the inner part of exposed sutures and were interpreted as a consequence of the hydrolytic attack to intralamellar regions. © 2013 Elsevier Ltd. All rights reserved.
CitacióMarquez, Y. [et al.]. Study on the hydrolytic degradation of the segmented GL-b-[GL-co-TMC-co-CL] -b-GL copolymer with application as monofilar surgical suture. "Polymer degradation and stability", Desembre 2013, vol. 98, núm. 12, p. 2709-2721.
ISSN0141-3910
Fitxers | Descripció | Mida | Format | Visualitza |
---|---|---|---|---|
polymer.pdf | 3,669Mb | Accés restringit |