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Rimonabant dimorphism and its pressure–temperature phasegiagram: A delicate case of overall monotropic behavior
dc.contributor.author | Perrin, Marc-Antoine |
dc.contributor.author | Bauer, Michel |
dc.contributor.author | Barrio Casado, María del |
dc.contributor.author | Tamarit Mur, José Luis |
dc.contributor.author | Céolin, René |
dc.contributor.author | Rietveld, Ivo B. |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear |
dc.date.accessioned | 2014-01-17T12:38:42Z |
dc.date.created | 2013-05-20 |
dc.date.issued | 2013-05-20 |
dc.identifier.citation | Perrin, M. [et al.]. Rimonabant dimorphism and its pressure–temperature phasegiagram: A delicate case of overall monotropic behavior. "Journal of Pharmaceutical Sciences", 20 Maig 2013, vol. 102, núm. 7, p. 2311-2321. |
dc.identifier.issn | 1520-6017 |
dc.identifier.uri | http://hdl.handle.net/2117/21266 |
dc.description.abstract | Crystalline polymorphism occurs frequently in the solid state of active pharmaceutical ingredients, and this is problematic for the development of a suitable dose form. Rimonabant, an active pharmaceutical ingredient developed by Sanofi and discontinued because of side effects, exhibits dimorphism; both solid forms have nearly the same melting temperatures, melting enthalpies, and specific volumes. Although the problem may well be academic from an industrial point of view, the present case demonstrates the usefulness of constructing pressure–temperature phase diagrams by direct measurement as well as by topological approach. The system is overall monotropic and form II is the more stable solid form. Interestingly, the more stable form does not possess any hydrogen bonds, whereas the less stable one does. |
dc.format.extent | 11 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Farmacologia |
dc.subject | Àrees temàtiques de la UPC::Enginyeria química::Química física |
dc.subject.lcsh | Pharmaceutical chemistry |
dc.subject.other | API |
dc.subject.other | polymorphism |
dc.subject.other | topological phase diagram |
dc.subject.other | Clapeyron equation |
dc.subject.other | crystal structure |
dc.subject.other | high pressure |
dc.subject.other | thermal analysis |
dc.subject.other | thermodynamics |
dc.subject.other | stability |
dc.title | Rimonabant dimorphism and its pressure–temperature phasegiagram: A delicate case of overall monotropic behavior |
dc.type | Article |
dc.subject.lemac | Farmacologia |
dc.contributor.group | Universitat Politècnica de Catalunya. GCM - Grup de Caracterització de Materials |
dc.identifier.doi | 10.1002/jps.23612 |
dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1002/jps.23612/abstract |
dc.rights.access | Restricted access - publisher's policy |
local.identifier.drac | 12892001 |
dc.description.version | Postprint (published version) |
dc.date.lift | 10000-01-01 |
local.citation.author | Perrin, M.; Bauer, M.; Del Barrio, M.; Tamarit, J.; Céolin, R.; Rietveld, I.R. |
local.citation.publicationName | Journal of Pharmaceutical Sciences |
local.citation.volume | 102 |
local.citation.number | 7 |
local.citation.startingPage | 2311 |
local.citation.endingPage | 2321 |
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