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A bioactive elastin-like recombinamer reduces unspecific protein adsorption and enhances cell response on titanium surfaces.
dc.contributor.author | Salvagni, Emiliano |
dc.contributor.author | Berguig, Geoffrey |
dc.contributor.author | Engel López, Elisabeth |
dc.contributor.author | Rodriguez Cabello, Jose Carlos |
dc.contributor.author | Coullerez, Geraldine |
dc.contributor.author | Textor, Marcus |
dc.contributor.author | Planell Estany, Josep Anton |
dc.contributor.author | Gil Mur, Francisco Javier |
dc.contributor.author | Aparicio Bádenas, Conrado José |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica |
dc.contributor.other | Institut de Bioenginyeria de Catalunya |
dc.date.accessioned | 2013-12-04T09:18:39Z |
dc.date.created | 2013-10-17 |
dc.date.issued | 2013-10-17 |
dc.identifier.citation | Salvagni, E. [et al.]. A bioactive elastin-like recombinamer reduces unspecific protein adsorption and enhances cell response on titanium surfaces.. "Colloids and Surfaces B. Biointerfaces", 17 Octubre 2013, vol. 17, núm. 114C, p. 225-233. |
dc.identifier.issn | 0927-7765 |
dc.identifier.uri | http://hdl.handle.net/2117/20907 |
dc.description.abstract | We present the immobilization on synthetic substrates of elastin-like recombinamers (ELR) that combine a bioactive motif for cell adhesion with protein antifouling properties. Physical adsorption of the recombinamers and covalent-grafting through organosilane chemistry were investigated. The biochemically-modified surfaces were thoroughly characterized and tested for protein absorption in serum by fluorescence-labelling, XPS, Ellipsometry, and OWLS. The ELR were successfully grafted and stable, even upon mechanical stresses; being the covalent bonding favourable over physical adsorption. The coated metal surfaces exhibited excellent reduction of serum protein adsorption (9 ng/cm2) compared to the bare metal surface (310 ng/cm2). Non-specific protein adsorption may mask the introduced bioactive motifs; therefore, the bioactivated surfaces should display serum-protein antifouling properties. Finally, improved hMSCs response was assessed on the bioactivated substrates. In summary, the coatings simultaneously displayed anti-fouling and bioactive properties. These studies investigated key factors to enhance tissue material interactions fundamental for the design of bioactive devices and future biomedical applications. |
dc.format.extent | 9 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials |
dc.subject.lcsh | Biomimetics |
dc.title | A bioactive elastin-like recombinamer reduces unspecific protein adsorption and enhances cell response on titanium surfaces. |
dc.type | Article |
dc.subject.lemac | Biomimètica |
dc.contributor.group | Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits |
dc.identifier.doi | 10.1016/j.colsurfb.2013.10.008 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S092777651300636X |
dc.rights.access | Restricted access - publisher's policy |
local.identifier.drac | 12912551 |
dc.description.version | Postprint (published version) |
dc.relation.projectid | info:eu-repo/grantAgreement/EC/FP7/263363/EU/Novel biomimetic strategy for bone regeneration/INNOVABONE |
dc.relation.projectid | info:eu-repo/grantAgreement/EC/FP7/278557/EU/Tissue in Host Engineering Guided Regeneration of Arterial Intimal Layer/THE GRAIL |
dc.date.lift | 10000-01-01 |
dc.contributor.covenantee | University of Minnesota School of Dentistry |
dc.contributor.covenantee | Universidad de Valladolid |
local.citation.author | Salvagni, E.; Berguig, G.; Engel, E.; Rodriguez-Cabello , J.C.; Coullerez, G.; Textor, M.; Planell, J.; Gil, F.J.; Aparicio, C. |
local.citation.publicationName | Colloids and Surfaces B. Biointerfaces |
local.citation.volume | 17 |
local.citation.number | 114C |
local.citation.startingPage | 225 |
local.citation.endingPage | 233 |
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