An adaptive meshfree method for phase-field models of biomembranes. Part II: A Lagrangian approach for membranes in viscous fluids
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Projecte de la Comissió EuropeaPREDMODSIM - Predictive models and simulations in nano- and biomolecular mechanics: a multiscale approach (EC-FP7-240487)
We present a Lagrangian phase-field method to study the low Reynolds number dynamics of vesicles embedded in a viscous fluid. In contrast to previous approaches, where the field variables are the phase-field and the fluid velocity, here we exploit the fact that the phasefield tracks a material interface to reformulate the problem in terms of the Lagrangian motion of a background medium, containing both the biomembrane and the fluid. We discretize the equations in space with maximum-entropy approximants, carefully shown to perform well in phase-field models of biomembranes in a companion paper. The proposed formulation is variational, lending itself to implicit time-stepping algorithms based on minimization of a time-incremental energy, which are automatically nonlinearly stable. The proposed method deals with two of the major challenges in the numerical treatment of coupled fluid/phase-field models of biomembranes, namely the adaptivity of the grid to resolve the sharp features of the phase-field, and the stiffness of the equations, leading to very small time-steps. In our method, local refinement follows the features of the phasefield as both are advected by the Lagrangian motion, and large time-steps can be robustly chosen in the variational time-stepping algorithm, which also lends itself to time adaptivity. The method is presented in the axisymmetric setting, but it can be directly extended to 3D.
CitacióPeco, C.; Arroyo, M.; Rosolen, A. An adaptive meshfree method for phase-field models of biomembranes. Part II: A Lagrangian approach for membranes in viscous fluids. "Journal of computational physics", Setembre 2013, vol. 249, núm. 5, p. 320-336.
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