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Control of microenvironmental cues with a smart biomaterial composite promotes endothelial progenitor cell angiogenesis
dc.contributor.author | Aguirre, Adrián |
dc.contributor.author | Gonzalez, Arlyng |
dc.contributor.author | Navarro, Melba |
dc.contributor.author | Castaño Linares, Óscar |
dc.contributor.author | Planell Estany, Josep Anton |
dc.contributor.author | Engel López, Elisabeth |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica |
dc.contributor.other | Institut de Bioenginyeria de Catalunya |
dc.date.accessioned | 2013-06-29T10:32:23Z |
dc.date.available | 2013-06-29T10:32:23Z |
dc.date.created | 2012-09 |
dc.date.issued | 2012-09 |
dc.identifier.citation | Aguirre, A. [et al.]. Control of microenvironmental cues with a smart biomaterial composite promotes endothelial progenitor cell angiogenesis. "European cells and materials", Setembre 2012, vol. 24, p. 90-106. |
dc.identifier.issn | 1473-2262 |
dc.identifier.uri | http://hdl.handle.net/2117/19725 |
dc.description.abstract | Smart biomaterials play a key role when aiming at successful tissue repair by means of regenerative medicine approaches, and are expected to contain chemical as well as mechanical cues that will guide the regenerative process. Recent advances in the understanding of stem cell biology and mechanosensing have shed new light onto the importance of the local microenvironment in determining cell fate. Herein we report the biological properties of a bioactive, biodegradable calcium phosphate glass/polylactic acid composite biomaterial that promotes bone marrowderived endothelial progenitor cell (EPC) mobilisation, differentiation and angiogenesis through the creation of a controlled bone healing-like microenvironment. The angiogenic response is triggered by biochemical and mechanical cues provided by the composite, which activate two synergistic cell signalling pathways: a biochemical one mediated by the calcium-sensing receptor and a mechanosensitive one regulated by non-muscle myosin II contraction. Together, these signals promote a synergistic response by activating EPCs-mediated VEGF and VEGFR-2 synthesis, which in turn promote progenitor cell homing, differentiation and tubulogenesis. These findings highlight the importance of controlling microenvironmental cues for stem/progenitor cell tissue engineering and offer exciting new therapeutical opportunities for biomaterialbased vascularisation approaches and clinical applications |
dc.format.extent | 17 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials |
dc.subject | Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Medicina interna |
dc.subject.lcsh | Calcium phosphate |
dc.subject.lcsh | Biomedical materials |
dc.subject.other | Calcium phosphate glass composite |
dc.subject.other | smart biomaterial |
dc.subject.other | endothelial progenitor cell |
dc.subject.other | angiogenesis |
dc.subject.other | mechanosensing |
dc.subject.other | calcium-sensing receptor |
dc.title | Control of microenvironmental cues with a smart biomaterial composite promotes endothelial progenitor cell angiogenesis |
dc.type | Article |
dc.subject.lemac | Biomaterials |
dc.subject.lemac | Enginyeria biomèdica |
dc.contributor.group | Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits |
dc.rights.access | Open Access |
local.identifier.drac | 10979732 |
dc.description.version | Postprint (published version) |
dc.relation.projectid | info:eu-repo/grantAgreement/EC/FP7/214402/EU/Angiogenesis-inducing Bioactive and Bioresponsive Scaffolds in Tissue Enginering/ANGIOSCAFF |
local.citation.author | Aguirre, A.; Gonzalez, A.; Navarro, M.; Castaño, O.; Planell, J.; Engel, E. |
local.citation.publicationName | European cells and materials |
local.citation.volume | 24 |
local.citation.startingPage | 90 |
local.citation.endingPage | 106 |
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