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Mechanisms of abdominal distension in severe intestinal dysmotility: abdomino-thoracic response to gut retention
dc.contributor.author | Barba, Elisabeth |
dc.contributor.author | Quiroga, Santi |
dc.contributor.author | Accarino, Anna |
dc.contributor.author | Monclús Lahoya, Eva |
dc.contributor.author | Malagelada, C |
dc.contributor.author | Burri, E |
dc.contributor.author | Navazo Álvaro, Isabel |
dc.contributor.author | Malagelada, J |
dc.contributor.author | Azpiroz, Fernando |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Llenguatges i Sistemes Informàtics |
dc.date.accessioned | 2013-06-19T12:35:59Z |
dc.date.created | 2013 |
dc.date.issued | 2013 |
dc.identifier.citation | Barba, E. [et al.]. Mechanisms of abdominal distension in severe intestinal dysmotility: abdomino-thoracic response to gut retention. "Neurogastroenterology and motility", 2013, vol. 25, núm. 6, p. e389-e394. |
dc.identifier.issn | 1350-1925 |
dc.identifier.uri | http://hdl.handle.net/2117/19579 |
dc.description.abstract | BACKGROUND: We previously showed that abdominal distension in patients with functional gut disorders is due to a paradoxical diaphragmatic contraction without major increment in intraabdominal volume. Our aim was to characterize the pattern of gas retention and the abdomino-thoracic mechanics associated with abdominal distension in patients with intestinal dysmotility. METHODS: In 15 patients with manometrically proven intestinal dysmotility, two abdominal CT scans were performed: one during basal conditions and other during an episode of severe abdominal distension. In 15 gender- and age-matched healthy controls, a basal scan was performed. KEY RESULTS: In basal conditions, patients exhibited more abdominal gas than healthy subjects, particularly in the small bowel, and the volume significantly increased during an episode of distension. During episodes of abdominal distension, the increase in abdominal content was associated with increased girth and antero-posterior abdominal diameter, as well as a cephalic displacement of the diaphragm, which reduced the height of the lung. The consequent reduction in the air volume of the lung was attenuated by an increase in the antero-posterior diameter of the chest. CONCLUSIONS & INFERENCES: Abdominal distension in patients with severe intestinal dysfunction is related to marked pooling of gut contents, particularly in the small bowel. This increase in content is accommodated within the abdominal cavity by a global and coordinated abdomino-phreno-thoracic response, involving an accommodative ascent of the diaphragm and a compensatory expansion of the chest wall. |
dc.language.iso | eng |
dc.subject | Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica |
dc.subject.lcsh | Intestinal diseases |
dc.subject.other | abdominal bloating |
dc.subject.other | abdominal distension |
dc.subject.other | intestinal dysmotility |
dc.subject.other | intestinal gas |
dc.subject.other | intestinal pseudoobstruction |
dc.title | Mechanisms of abdominal distension in severe intestinal dysmotility: abdomino-thoracic response to gut retention |
dc.type | Article |
dc.subject.lemac | Intestins -- Malalties |
dc.contributor.group | Universitat Politècnica de Catalunya. MOVING - Grup de Recerca en Modelatge, Interacció i Visualització en Realitat Virtual |
dc.identifier.doi | 10.1111/nmo.12128 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://www.ncbi.nlm.nih.gov/pubmed/23607758 |
dc.rights.access | Restricted access - author's decision |
local.identifier.drac | 12495813 |
dc.description.version | Postprint (published version) |
dc.date.lift | 10000-01-01 |
local.citation.author | Barba, E.; Quiroga, S.; Accarino, A.; Monclús, E.; Malagelada, C.; Burri, E.; Navazo, I.; Malagelada, J.; Azpiroz, F. |
local.citation.publicationName | Neurogastroenterology and motility |
local.citation.volume | 25 |
local.citation.number | 6 |
local.citation.startingPage | e389 |
local.citation.endingPage | e394 |
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