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Influence of electrical stimulation on 3D-cultures of Adipose Tissue Derived Progenitor Cells (ATDPCs) behavior
dc.contributor.author | Castells-Sala, C. |
dc.contributor.author | Sánchez Terrones, Benjamín |
dc.contributor.author | Recha-Sancho, L. |
dc.contributor.author | Puig, V. |
dc.contributor.author | Bragós Bardia, Ramon |
dc.contributor.author | Semino, C.E. |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica |
dc.date.accessioned | 2013-02-21T09:59:28Z |
dc.date.created | 2012 |
dc.date.issued | 2012 |
dc.identifier.citation | Castells-Sala, C. [et al.]. Influence of electrical stimulation on 3D-cultures of Adipose Tissue Derived Progenitor Cells (ATDPCs) behavior. A: IEEE Engineering in Medicine and Biology Society. "34th Annual International Conference of the IEEE EMBS San Diego, California USA, 28 August-1 September, 2012". San Diego, California: IEEE, 2012, p. 5658-5661. |
dc.identifier.isbn | 978-1-4577-1787-1/12 |
dc.identifier.uri | http://hdl.handle.net/2117/17903 |
dc.description.abstract | Tissue engineering has a fundamental role in regenerative medicine. Still today, the major motivation for cardiac regeneration is to design a platform that enables the complete tissue structure and physiological function regeneration of injured myocardium areas. Although tissue engineering approaches have been generally developed for two-dimensional (2D) culture systems, three-dimensional (3D) systems are being spotlighted as the means to mimic better in vivo cellular conditions. This manuscript examines the influence of electrical stimulation on 3D cultures of adipose tissue-derived progenitor cells (ATDPCs). ATDPCs cells were encapsulated into a self-assembling peptide nanoscaffold (RAD16-I) and continuously electro stimulated during 14-20 days with 2-ms pulses of 50mV/cm at a frequency of 1 Hz. Good cellular network formation and construct diameter reduction was observed in electro stimulated samples. Importantly, the process of electro stimulation does not disrupt cell viability or connectivity. As a future outlook, differentiation studies to cardiomyocytes-like cells will be performed analyzing gene profile and protein expression. |
dc.format.extent | 4 p. |
dc.language.iso | eng |
dc.publisher | IEEE |
dc.subject | Àrees temàtiques de la UPC::Enginyeria electrònica::Instrumentació i mesura |
dc.subject | Àrees temàtiques de la UPC::Enginyeria biomèdica::Electrònica biomèdica |
dc.subject.lcsh | Biomedical engineering |
dc.subject.lcsh | Electric stimulation |
dc.title | Influence of electrical stimulation on 3D-cultures of Adipose Tissue Derived Progenitor Cells (ATDPCs) behavior |
dc.type | Conference report |
dc.subject.lemac | Enginyeria biomèdica |
dc.subject.lemac | Estimulació elèctrica |
dc.contributor.group | Universitat Politècnica de Catalunya. IEB - Instrumentació Electrònica i Biomèdica |
dc.description.awardwinning | Award-winning |
dc.rights.access | Restricted access - publisher's policy |
local.identifier.drac | 10806488 |
dc.description.version | Postprint (published version) |
dc.date.lift | 10000-01-01 |
local.citation.author | Castells-Sala, C.; Sánchez, B.; Recha-Sancho, L.; Puig, V.; Bragos, R.; Semino, C. |
local.citation.contributor | IEEE Engineering in Medicine and Biology Society |
local.citation.pubplace | San Diego, California |
local.citation.publicationName | 34th Annual International Conference of the IEEE EMBS San Diego, California USA, 28 August-1 September, 2012 |
local.citation.startingPage | 5658 |
local.citation.endingPage | 5661 |