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Statistical considerations when using a composite endpoint for comparing treatment groups
dc.contributor.author | Gómez Melis, Guadalupe |
dc.contributor.author | Lagakos, Stephen W. |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa |
dc.date.accessioned | 2012-12-18T10:53:34Z |
dc.date.created | 2012-08 |
dc.date.issued | 2012-08 |
dc.identifier.citation | Gomez, G.; Lagakos, S. Statistical considerations when using a composite endpoint for comparing treatment groups. "Statistics in medicine", Agost 2012. |
dc.identifier.issn | 0277-6715 |
dc.identifier.uri | http://hdl.handle.net/2117/17142 |
dc.description.abstract | When comparing two treatment groups in a time-to-event analysis, it is common to use a composite event consisting of two or more distinct outcomes. The goal of this paper is to develop a statistical methodology to derive efficiency guidelines for deciding whether to expand a study primary endpoint from E1 (for example, non-fatal myocardial infarction and cardiovascular death) to the composite of E1 and E2 (for example, non-fatal myocardial infarction, cardiovascular death or revascularisation). We investigate this problem by considering the asymptotic relative efficiency of a log-rank test for comparing treatment groups with respect to a primary relevant endpoint E1 versus the composite primary endpoint, say E , of E1 and E2, where E2 is some additional endpoint |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Matemàtiques i estadística::Estadística aplicada |
dc.subject.lcsh | Statistics |
dc.subject.lcsh | Medicine |
dc.title | Statistical considerations when using a composite endpoint for comparing treatment groups |
dc.type | Article |
dc.subject.lemac | Estadística aplicada -- Medicina |
dc.contributor.group | Universitat Politècnica de Catalunya. GREMA - Grup de Recerca en Estadística Matemàtica i les seves Aplicacions |
dc.identifier.doi | 10.1002/sim.5547 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1002/sim.5547/pdf |
dc.rights.access | Restricted access - publisher's policy |
local.identifier.drac | 11149866 |
dc.description.version | Postprint (published version) |
dc.date.lift | 10000-01-01 |
local.citation.author | Gomez, G.; Lagakos, S. |
local.citation.publicationName | Statistics in medicine |
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