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Modification of microbial polymalic acid with hydrophobic amino acids for drug-releasing nanoparticles
dc.contributor.author | Lanz, Alberto |
dc.contributor.author | García Álvarez, Montserrat |
dc.contributor.author | Portilla Arias, Jose Antonio |
dc.contributor.author | Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon |
dc.contributor.author | Holler, Eggehard |
dc.contributor.author | Ljubimova, Julia Y. |
dc.contributor.author | Muñoz Guerra, Sebastián |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química |
dc.date.accessioned | 2012-11-07T11:06:30Z |
dc.date.created | 2012-08-14 |
dc.date.issued | 2012-08-14 |
dc.identifier.citation | Lanz, A. [et al.]. Modification of microbial polymalic acid with hydrophobic amino acids for drug-releasing nanoparticles. "Macromolecular chemistry and physics", 14 Agost 2012, vol. 213, núm. 15, p. 1623-1631. |
dc.identifier.issn | 1022-1352 |
dc.identifier.uri | http://hdl.handle.net/2117/16855 |
dc.description.abstract | Microbial poly( β , L -malic acid) was modifi ed with either L -leucine ethyl ester (L) or L -phenylalanine methyl ester (F) to produce amphiphylic copolymers. The degradation of these copolymers in aqueous buffer took place under physiological conditions in a few weeks by hydrolysis of the side chain ester group followed by cleavage of the main chain. Spherical nanoparticles with diameters ranging between 70 and 230 nm were prepared from these copolymers by the dialysis-precipitation method. No alteration of the cell viability was observed after incubation of these nanoparticles in different cell lines. Anticancer drugs temozolomide and doxorubicin were encapsulated in the nanoparticles. Temozolomide was released within several hours whereas doxorubicin took several weeks to be completely liberated. |
dc.format.extent | 9 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria química |
dc.subject.lcsh | Polymers |
dc.title | Modification of microbial polymalic acid with hydrophobic amino acids for drug-releasing nanoparticles |
dc.type | Article |
dc.subject.lemac | Polímers |
dc.contributor.group | Universitat Politècnica de Catalunya. POL - Polímers Industrials Avançats i Biopolímers Tecnològics |
dc.identifier.doi | 10.1002/macp.201200134 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1002/macp.201200134/full |
dc.rights.access | Restricted access - publisher's policy |
local.identifier.drac | 11020841 |
dc.description.version | Postprint (published version) |
dc.date.lift | 10000-01-01 |
local.citation.author | Lanz, A.; Garcia, M.; Portilla, J.; Martinez de Ilarduya, D.; Holler, E.; Ljubimova, J.; Muñoz, S. |
local.citation.publicationName | Macromolecular chemistry and physics |
local.citation.volume | 213 |
local.citation.number | 15 |
local.citation.startingPage | 1623 |
local.citation.endingPage | 1631 |
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