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Microbial poly( β , L -malic acid) was modifi ed with either L -leucine ethyl ester (L) or L -phenylalanine
methyl ester (F) to produce amphiphylic copolymers. The degradation of these copolymers
in aqueous buffer took place under physiological conditions in a few weeks by hydrolysis
of the side chain ester group followed by cleavage of the
main chain. Spherical nanoparticles with diameters ranging
between 70 and 230 nm were prepared from these copolymers
by the dialysis-precipitation method. No alteration of the cell
viability was observed after incubation of these nanoparticles
in different cell lines. Anticancer drugs temozolomide and
doxorubicin were encapsulated in the nanoparticles. Temozolomide
was released within several hours whereas doxorubicin
took several weeks to be completely liberated.
CitacióLanz, A. [et al.]. Modification of microbial polymalic acid with hydrophobic amino acids for drug-releasing nanoparticles. "Macromolecular chemistry and physics", 14 Agost 2012, vol. 213, núm. 15, p. 1623-1631.