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dc.contributor.authorPacini, Aurora
dc.contributor.authorCaricato, Marco
dc.contributor.authorFerrari, Stefania
dc.contributor.authorCapsoni, Doretta
dc.contributor.authorMartínez de Ilarduya Sáez de Asteasu, Domingo Antxon
dc.contributor.authorMuñoz Guerra, Sebastián
dc.contributor.authorPasini, Dario
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2012-10-19T08:37:43Z
dc.date.created2012-11-15
dc.date.issued2012-11-15
dc.identifier.citationPacini, A. [et al.]. Poly(gamma-glutamic acid) esters with reactive functional groups suitable for orthogonal conjugation strategies. "Journal of polymer science. Part A, polymer chemistry", 15 Novembre 2012, vol. 50, núm. 22, p. 4790-4799.
dc.identifier.issn0887-624X
dc.identifier.urihttp://hdl.handle.net/2117/16756
dc.description.abstractWe report on a series of novel poly(c-glutamic acid) (PGGA) esters, in which the chemical structure and composition, and the molecular weight are systematically changed. Modification of PGGA of microbial origin, used either as the sodium salt or in the free acid form, by means of alkylation with highly reactive bromides under SN2 conditions, affords copolymers with an essentially random microstructure. These reaction conditions are applied iteratively to achieve full esterification, obtaining allyl or propargyl ester functionalities within the polymer backbone, diluted with inert functional groups, such as benzyl, ethyl, or hexyl ester functionalities. The copolymers have been characterized regarding their chemical structure and thermal and bulk properties using nuclear magnetic resonance, thermogravimetry, differential scanning calorimetry, and X-ray diffraction techniques. We demonstrate that allyl and propargyl ester groups can be efficiently transformed using click chemistries, such as thiol-ene or copper(I)- catalyzed azide–alkyne cycloaddition reactions; such efficient conjugation strategies will be required to transformthe native bacterial biopolymer into a material with tailored properties for bulk scale or biomedical applications.
dc.format.extent10 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshBiopolymers
dc.subject.lcshPolyamides
dc.titlePoly(gamma-glutamic acid) esters with reactive functional groups suitable for orthogonal conjugation strategies
dc.typeArticle
dc.subject.lemacBiopolímers
dc.subject.lemacPoliamides
dc.contributor.groupUniversitat Politècnica de Catalunya. POL - Polímers Industrials Avançats i Biopolímers Tecnològics
dc.identifier.doi10.1002/pola.26363
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1002/pola.26363/abstract
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac10978713
dc.description.versionPostprint (published version)
dc.date.lift10000-01-01
local.citation.authorPacini, A.; Caricato, M.; Ferrari, S.; Capsoni, D.; Martinez de Ilarduya, A.; Muñoz, S.; Pasini, D.
local.citation.publicationNameJournal of polymer science. Part A, polymer chemistry
local.citation.volume50
local.citation.number22
local.citation.startingPage4790
local.citation.endingPage4799


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