Preparation of biodegradable polylactide microparticles via a biocompatible procedure
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PLA MPs are prepared via a novel and toxic-chemical-free fabrication route using ethyl lactate, a green solvent and FDA-approved aroma. MPs are obtained by a solution jet break-up and solvent displacement method. Adjusting flow parameters allows the tuning of MPs size between 60 and 180 mm, with reduced polydispersity. Morphological analysis shows microporous particles with Janus-like surface. A fluorophore is successfully loaded into the MPs during their formation step. This versatile green solvent-based procedure is proven to be suitable for drug encapsulation and delivery applications. The method may be extended to different droplet generation techniques.
CitationLevato, R.; Mateos, M.; Planell, J. Preparation of biodegradable polylactide microparticles via a biocompatible procedure. "Macromolecular bioscience", Abril 2012, vol. 12, núm. 4, p. 557-566.