Slow pulse due to calcium current induces phase-2 reentry in heterogeneous tissue
Document typeConference report
Rights accessRestricted access - publisher's policy
Phase-2 reentry is a basic mechanism for the transition to VT and VF in the heart. It is thought to underly many causes of idiopathic ventricular arrhythmias as, for instance, those occurring in Brugada syndrome. Reentry is usually linked to heterogeneity in tissue repolarization. We study some circunstances under which a region of depolarized tissue can reexcite adjacent regions that exhibit shorter action potential duration (APD), eventually inducing reentry. Simulations are performed using a simplified ionic model that reproduces well the ventricular action potential (AP). We analyze first the conditions that lead to very short action potentials (APs). Then, we show that reexcitation takes place via a slow (calcium current induced) pulse that propagates into the region of short APs until it encounters excitable tissue. In two dimensions, this may give rise to reentry with the formation of counter-rotating spiral waves
CitationPeñaranda, A.; Cantalapiedra, I. R.; Echebarria, B. Slow pulse due to calcium current induces phase-2 reentry in heterogeneous tissue. A: Computing in Cardiology. "Computing in Cardiology 2010: scientific program". Belfast: 2010, p. 661-664.