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Silicon-stabilized alpha-tricalcium phosphate and its use in a calcium phosphate cement: characterization and cell response
dc.contributor.author | Mestres Beà, Gemma |
dc.contributor.author | Le Van, Clemence |
dc.contributor.author | Ginebra Molins, Maria Pau |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica |
dc.date.accessioned | 2012-02-13T12:54:34Z |
dc.date.available | 2012-02-13T12:54:34Z |
dc.date.created | 2012-01-31 |
dc.date.issued | 2012-01-31 |
dc.identifier.citation | Mestres, G.; Le Van, C.; Ginebra, M.P. Silicon-stabilized alpha-tricalcium phosphate and its use in a calcium phosphate cement: characterization and cell response. "Acta biomaterialia", 31 Gener 2012, vol. 8, núm. 3, p. 1169-1179. |
dc.identifier.issn | 1742-7061 |
dc.identifier.uri | http://hdl.handle.net/2117/15097 |
dc.description.abstract | α-Tricalcium phosphate (α-TCP) is widely used as a reactant in calcium phosphate cements. This work aims at doping α-TCP with silicon with a twofold objective. On the one hand, to study the effect of Si addition on the stability and reactivity of this polymorph. On the other, to develop Si-doped cements and to evaluate the effect of Si on their in vitro cell response. For this purpose a calcium-deficient hydroxyapatite was sintered at 1250 °C with different amounts of silicon oxide. The high temperature polymorph α-TCP was stabilized by the presence of silicon, which inhibited reversion of the β → α transformation, whereas in the Si-free sample α-TCP completely reverted to the β-polymorph. However, the β–α transformation temperature was not affected by the presence of Si. Si–α-TCP and its Si-free counterpart were used as reactants for a calcium phosphate cement. While Si–α-TCP showed faster hydrolysis to calcium-deficient hydroxyapatite, upon complete reaction the crystalline phases, morphology and mechanical properties of both cements were similar. An in vitro cell culture study, in which osteoblast-like cells were exposed to the ions released by both materials, showed a delay in cell proliferation in both cases and stimulation of cell differentiation, more marked for the Si-containing cement. These results can be attributed to strong modification of the ionic concentrations in the culture medium by both materials. Ca-depletion from the medium was observed for both cements, whereas continuous Si release was detected for the Si-containing cement. |
dc.format.extent | 11 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria dels materials |
dc.subject.lcsh | Calcium phosphate |
dc.subject.lcsh | Biomedical materials |
dc.title | Silicon-stabilized alpha-tricalcium phosphate and its use in a calcium phosphate cement: characterization and cell response |
dc.type | Article |
dc.subject.lemac | Ciment (Biomedicina) |
dc.subject.lemac | Biomaterials |
dc.subject.lemac | Fosfat de calci |
dc.subject.lemac | Silici |
dc.contributor.group | Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits |
dc.identifier.doi | 10.1016/j.actbio.2011.11.021 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S1742706111005228 |
dc.rights.access | Restricted access - publisher's policy |
local.identifier.drac | 9589035 |
dc.description.version | Postprint (published version) |
local.citation.author | Mestres, G.; Le Van, C.; Ginebra, M.P. |
local.citation.publicationName | Acta biomaterialia |
local.citation.volume | 8 |
local.citation.number | 3 |
local.citation.startingPage | 1169 |
local.citation.endingPage | 1179 |
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