Condicions d'accésAccés restringit per política de l'editorial
Calcium phosphate compounds can potentially influence cellular fate through ionic substitutions. However,
to be able to turn such solution-mediated processes into successful directors of cellular response, a
perfect understanding of the material-induced chemical reactions in situ is required. We therefore report
on the application of home-made electrochemical microelectrodes, tested as pH and chloride sensors, for
precise spatial and temporal characterization of different aqueous environments around calcium phosphate-
based biomaterials prepared from a-tricalcium phosphate using clinically relevant liquid to powder
ratios. The small size of the electrodes allowed for online measurements in traditionally inaccessible
in vitro environments, such as the immediate material–liquid interface and the interior of curing bone
cement. The kinetic data obtained has been compared to theoretical sorption models, confirming that
the proposed setup can provide key information for improved understanding of the biochemical environment
imposed by chemically reactive biomaterials.
CitacióGustavsson, J. [et al.]. Electrochemical microelectrodes for improved spatial and temporal characterization of aqueous environments around calcium phosphate cements.. "Acta biomaterialia", 07 Octubre 2011, vol. 8, núm. 1, p. 386-393.