Towards establishing electrical interfaces with patterned in vitro neurons, we have previously described the fabrication of hybrid elastomer-glass devices polymer-on-multielectrode array technology and obtained single-electrode recordings of extracellular potentials from confined neurons (Claverol-Tinturé et al., 2005). Here, we demonstrate the feasibility of spatially localized multisite recordings from individual microchannel-guided neurites extending from microwell-confined somas with good signal-to-noise ratios (20 dB) and spike magnitudes of up to 300 μV.
Single-cell current source density (scCSD) analysis of the spatio-temporal
patterns of membrane currents along individual processes is illustrated.
CitationClaverol-Tinture, E; Cabestany, J; Rosell, X.. Multisite recording of extracellular potentials produced by microchannel-confined neurons in-vitro . IEEE Transactions on Biomedical Engineering 2007, vol. 54 núm.2, p. 331-335
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