Biological tissue characterization by magnetic induction spectroscopy (MIS): requirements and limitations
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hdl:2117/1343
Tipus de documentArticle
Data publicació2003-07-31
EditorIEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
Condicions d'accésAccés obert
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Abstract
Magnetic induction spectroscopy (MIS) aims at the contactless measurement of the passive electrical properties (PEP) σ, ε, and μ of biological tissues via magnetic fields at multiple frequencies. Whereas previous publications focus on either the conductive or the magnetic aspect of inductive measurements, this article provides a synthesis of both concepts by discussing two different applications with the same measurement system: 1) monitoring of brain edema and 2) the estimation of hepatic iron stores in certain pathologies. We derived the equations to estimate the sensitivity of MIS as a function of the PEP of biological objects. The system requirements and possible systematic errors are analyzed for a MIS-channel using a planar gradiometer (PGRAD) as detector.We studied 4 important error sources: 1) moving conductors
near the PGRAD; 2) thermal drifts of the PGRAD-parameters; 3) lateral displacements of the PGRAD; and 4) phase drifts in the receiver. All errors were compared with the desirable resolution. All errors affect the detected imaginary part (mainly related
to σ ) of the measured complex field much less than the real part (mainly related to ε and μ). Hence, the presented technique renders possible the resolution of (patho-) physiological changes of the electrical conductivity when applying highly resolving hardware and elaborate signal processing. Changes of the magnetic permeability
and permittivity in biological tissues are more complicated to deal with and may require chopping techniques, e.g., periodic movement of the object.
CitacióScharfetter, H; Casañas, R; Rosell, J. Biological tissue characterization by magnetic induction spectroscopy (MIS): requirements and limitations. IEEE Transactions on Biomedical Engineering, 2003, vol. 50, núm.7 p. 870-880
ISSN0018-9294
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