|Títol: ||Preparation and release study of ibuprofen-loaded porous matrices of a biodegradable poly(ester amide) derived from L -alanine units|
|Autor: ||Valle Mendoza, Luis Javier del|
Franco García, María Lourdes
Puiggalí Bellalta, Jordi
Rodríguez Galán, Rafael Alfonso
|Altres autors/autores: ||Universitat Politècnica de Catalunya. Departament d'Enginyeria Química; Universitat Politècnica de Catalunya. Departament d'Enginyeria Agroalimentària i Biotecnologia; Universitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables.|
|Matèries: ||Àrees temàtiques de la UPC::Enginyeria química::Biotecnologia|
Àrees temàtiques de la UPC::Física::Física molecular::Física de polímers
Polymers -- Biocompatibility
Polímers -- Biotecnologia
|Tipus de document: ||Article|
|Descripció: ||Scaffolds of a biodegradable poly(ester amide)constituted of L-alanine, sebacic acid, and 1,12-dodecanediol units (abbreviated as PADAS) were prepared by the
compression-molding/particulate-leaching method. The influence of the type, size, and percentage of salt on the scaffold porosity and morphology was evaluated. The thermal
behavior and crystallinity were also studied for samples obtained under different processing conditions.
PADAS scaffolds were not cytotoxic because they showed good cell viability and supported cell growth at a similar ratio to that observed for the biocompatible materials used as a reference. The use of PADAS scaffolds as a drug-delivery system was also evaluated by the employment of ibuprofen, a drug with well known anti-inflammatory effects. Different drug-loading methods were considered, and their influence on the release in a so¨rensen’s medium was evaluated as well as the influence of the scaffold morphology.
A sustained release of ibuprofen could be attained without the production of a negative effect on the cell viability. The
release kinetics of samples loaded before melt processing was well described by the combined Higuchi/first-order model. This allowed the estimation of the diffusion coefficients, which ranged between 3x10‾14 and 5x10‾13 m2/ s. Samples loaded by immersion in ibuprofen solutions showed a rapid release that could be delayed by the addition of polycaprolactone to the immersion medium (i.e., the release rate decreased from 0.027 to 0.015 h‾1).|
Postprint (published version)
|Altres identificadors i accés: ||del Valle, LJ. [et al.]. Preparation and release study of ibuprofen-loaded porous matrices of a biodegradable poly(ester amide) derived from L -alanine units. "Journal of applied polymer science", Novembre 2011, vol. 122, núm. 3, p. 1953-1967.|
|Disponible al dipòsit:||E-prints UPC|
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