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dc.contributor.authorDíez Escudero, Anna
dc.contributor.authorEspañol Pons, Montserrat
dc.contributor.authorBeats, Sean
dc.contributor.authorGinebra Molins, Maria Pau
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2017-10-04T08:19:45Z
dc.date.available2019-09-15T00:25:52Z
dc.date.issued2017-09-15
dc.identifier.citationDiez, A., Español, M., Beats, S., Ginebra, M.P. In vitro degradation of calcium phosphates: Effect of multiscale porosity, textural properties and composition. "Acta biomaterialia", 15 Setembre 2017, vol. 60, p. 81-92.
dc.identifier.issn1742-7061
dc.identifier.urihttp://hdl.handle.net/2117/108310
dc.description.abstractThe capacity of calcium phosphates to be replaced by bone is tightly linked to their resorbability. However, the relative importance of some textural parameters on their degradation behavior is still unclear. The present study aims to quantify the effect of composition, specific surface area (SSA), and porosity at various length scales (nano-, micro- and macroporosity) on the in vitro degradation of different calcium phosphates. Degradation studies were performed in an acidic medium to mimic the osteoclastic environment. Small degradations were found in samples with interconnected nano- and micropores with sizes below 3 µm although they were highly porous (35–65%), with maximum weight loss of 8 wt%. Biomimetic calcium deficient hydroxyapatite, with high SSA and low crystallinity, presented the highest degradation rates exceeding even the more soluble ß-TCP. A dependence of degradation on SSA was indisputable when porosity and pore sizes were increased. The introduction of additional macroporosity with pore interconnections above 20 µm significantly impacted degradation, more markedly in the substrates with high SSA (>15 m2/g), whereas in sintered substrates with low SSA (<1 m2/g) it resulted just in a linear increase of degradation. Up to 30 % of degradation was registered in biomimetic substrates, compared to 15 % in ß-TCP or 8 % in sintered hydroxyapatite. The incorporation of carbonate in calcium deficient hydroxyapatite did not increase its degradation rate. Overall, the study highlights the importance of textural properties, which can modulate or even outweigh the effect of other features such as the solubility of the compounds. Statement of Significance The physicochemical features of calcium phosphates are crucial to tune biological events like resorption during bone remodeling. Understanding in vitro resorption can help to predict the in vivo behavior. Besides chemical composition, other parameters such as porosity and specific surface area have a strong influence on resorption. The complexity of isolating the contribution of each parameter lies in the close interrelation between them. In this work, a multiscale study was proposed to discern the extent to which each parameter influences degradation in a variety of calcium phosphates, using an acidic medium to resemble the osteoclastic environment. The results emphasize the importance of textural properties, which can modulate or even outweigh the effect of the intrinsic solubility of the compounds.
dc.format.extent12 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshCalcium Phosphates
dc.subject.lcshTissue engineering
dc.subject.otherCalcium phosphates
dc.subject.otherDegradation
dc.subject.otherPorosity
dc.subject.otherTextural properties
dc.titleIn vitro degradation of calcium phosphates: Effect of multiscale porosity, textural properties and composition
dc.typeArticle
dc.subject.lemacFosfat de calci
dc.subject.lemacEnginyeria de teixits
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1016/j.actbio.2017.07.033
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1742706117304713?via%3Dihub
dc.rights.accessOpen Access
local.identifier.drac21553705
dc.description.versionPostprint (author's final draft)
local.citation.authorDiez, A.; Español, M.; Beats, S.; Ginebra, M.P.
local.citation.publicationNameActa biomaterialia
local.citation.volume60
local.citation.startingPage81
local.citation.endingPage92


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