Estimation of the synaptic conductance in a McKean-model neuron
Tipus de documentComunicació de congrés
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Estimating the synaptic conductances impinging on a single neuron directly from its membrane potential is one of the open problems to be solved in order to understand the flow of information in the brain. Despite the existence of some computational strategies that give circumstantial solutions ([1-3] for instance), they all present the inconvenience that the estimation can only be done in subthreshold activity regimes. The main constraint to provide strategies for the oscillatory regimes is related to the nonlinearity of the input-output curve and the difficulty to compute it. In experimental studies it is hard to obtain these strategies and, moreover, there are no theoretical indications of how to deal with this inverse non-linear problem. In this work, we aim at giving a first proof of concept to address the estimation of synaptic conductances when the neuron is spiking. For this purpose, we use a simplified model of neuronal activity, namely a piecewise linear version of the Fitzhugh-Nagumo model, the McKean model (, among others), which allows an exact knowledge of the nonlinear f-I curve by means of standard techniques of non-smooth dynamical systems. As a first step, we are able to infer a steady synaptic conductance from the cell's oscillatory activity. As shown in Figure ¿Figure1,1, the model shows the relative errors of the conductances of order C, where C is the membrane capacitance (C<<1), notably improving the errors obtained using filtering techniques on the membrane potential plus linear estimations, see numerical tests performed in .
CitacióGuillamon, A., Prohens, R., Teruel, A., Vich, C. Estimation of the synaptic conductance in a McKean-model neuron. A: Annual Computational Neuroscience Meeting. "BMC Neuroscience 2015 16(Suppl 1) : 24th Annual Computational Neuroscience Meeting: CNS 2015 Meeting abstracts". Praga: 2015, p. 251.