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dc.contributor.authorBarrio Casado, María del
dc.contributor.authorHuguet, Jordi
dc.contributor.authorRobert, B.
dc.contributor.authorRietveld, Ivo B.
dc.contributor.authorCéolin, René
dc.contributor.authorTamarit Mur, José Luis
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Física
dc.date.accessioned2017-05-19T14:13:29Z
dc.date.available2017-05-19T14:13:29Z
dc.date.issued2017-06-15
dc.identifier.citationDel Barrio, M., Huguet, J., Robert, B., Rietveld, I., Céolin, R., Tamarit, J. L. Pressure-temperature phase diagram of the dimorphism of the anti-inflammatory drug nimesulide. "International journal of pharmaceutics", 15 Juny 2017, vol. 525, núm. 1, p. 54-59.
dc.identifier.issn0378-5173
dc.identifier.urihttp://hdl.handle.net/2117/104659
dc.description.abstractUnderstanding the phase behavior of active pharmaceutical ingredients is important for formulations of dosage forms and regulatory reasons. Nimesulide is an anti-inflammatory drug that is known to exhibit dimorphism; however up to now its stability behavior was not clear, as few thermodynamic data were available. Therefore, calorimetric melting data have been obtained, which were found to be TI-L = 422.4 ± 1.0 K, ¿I ¿ LH = 117.5 ± 5.2 J g-1, TII-L = 419.8 ± 1.0 K and ¿II ¿ LH = 108.6 ± 3.3 J g-1. In addition, vapor-pressure data, high-pressure melting data, and specific volumes have been obtained. It is demonstrated that form II is intrinsically monotropic in relation to form I and the latter would thus be the best polymorph to use for drug formulations. This result has been obtained by experimental means, involving high-pressure measurements. Furthermore, it has been shown that with very limited experimental and statistical data, the same conclusion can be obtained, demonstrating that in first instance topological pressure-temperature phase diagrams can be obtained without necessarily measuring any high-pressure data. It provides a quick method to verify the phase behavior of the known phases of an active pharmaceutical ingredient under different pressure and temperature conditions.
dc.format.extent6 p.
dc.language.isoeng
dc.subjectÀrees temàtiques de la UPC::Física
dc.subject.lcshCalorimetry
dc.subject.lcshCrystallography
dc.subject.lcshPolymorphism (Crystallography)
dc.subject.lcshThermodynamics
dc.subject.otherPolymorphism
dc.subject.otherThermodynamics
dc.subject.otherPressure-temperature phase diagram
dc.subject.otherPhase behavior
dc.subject.otherCrystallography
dc.subject.otherCalorimetry
dc.subject.otherPreformulation
dc.titlePressure-temperature phase diagram of the dimorphism of the anti-inflammatory drug nimesulide
dc.typeArticle
dc.subject.lemacTermodinàmica
dc.subject.lemacCristal·lografia
dc.subject.lemacCalorimetria
dc.subject.lemacPolimorfisme (Cristal·lografia)
dc.contributor.groupUniversitat Politècnica de Catalunya. GCM - Grup de Caracterització de Materials
dc.identifier.doi10.1016/j.ijpharm.2017.04.016
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0378517317302971
dc.rights.accessOpen Access
drac.iddocument20335644
dc.description.versionPostprint (author's final draft)
upcommons.citation.authorDel Barrio, M., Huguet, J., Robert, B., Rietveld, I., Céolin, R., Tamarit, J. Ll.
upcommons.citation.publishedtrue
upcommons.citation.publicationNameInternational journal of pharmaceutics
upcommons.citation.volume525
upcommons.citation.number1
upcommons.citation.startingPage54
upcommons.citation.endingPage59
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