Incorporation of chloramphenicol and captopril into poly(GL)-b-poly(GL-co-TMC-co-CL)-b-poly(GL) monofilar surgical sutures
Visualitza/Obre
Cita com:
hdl:2117/104122
Tipus de documentArticle
Data publicació2017-05-05
Condicions d'accésAccés obert
Tots els drets reservats. Aquesta obra està protegida pels drets de propietat intel·lectual i
industrial corresponents. Sense perjudici de les exempcions legals existents, queda prohibida la seva
reproducció, distribució, comunicació pública o transformació sense l'autorització del titular dels drets
Abstract
Incorporation of chloramphenicol and captopril into coated and uncoated monofilament sutures was evaluated, as well as the derived bactericide and wound healing effects. To this end, a commercially available suture and an amorphous random copolymer constituted by trimethylene carbonate and lactide units were considered. The suture had a segmented architecture based on polyglycolide hard blocks and a soft block constituted by glycolide, trimethylene carbonate and ε-caprolactone units. Chloramphenicol was better loaded when the coating copolymer was employed due to its protective effect whereas captopril showed an opposite behavior due to partial solubilization during immersion in the coating bath. Interestingly, the release behavior was very different for the two studied drugs since a significant retention of chloramphenicol was always detected, suggesting the establishment of interactions between drug and copolymers. On the other hand, delivery of captopril showed a typical dose dependent behavior. A low in vitro toxicity of the two drugs was determined considering both epithelial-like and fibroblast-like cells. Bactericide effect of chloramphenicol against Gram-negative and Gram-positive bacteria was demonstrated at a dose that was non-toxic for all assayed cells. An accelerating wound healing effect of captopril was also demonstrated for early events. In this case, the use of a coating copolymer was fundamental to avoid cytotoxic effects on highly loaded sutures.
CitacióMárquez, Y., Cabral, T., Lorenzetti, A., Franco, M., Turon, P., del Valle, LJ., Puiggali, J. Incorporation of chloramphenicol and captopril into poly(GL)-b-poly(GL-co-TMC-co-CL)-b-poly(GL) monofilar surgical sutures. "Journal of applied polymer science", 5 Maig 2017, vol. 134, núm. 44762.
ISSN0021-8995
Fitxers | Descripció | Mida | Format | Visualitza |
---|---|---|---|---|
INCORPORATION O ... HENICOL AND CAPTOPRIL.docx | 3,766Mb | Microsoft Word 2007 | Visualitza/Obre |