Osteoblast cells behaviour according to the physical and chemical properties of nanowires
Tutor / director / avaluadorVeith, Michael
Tipus de documentProjecte/Treball Final de Carrera
Condicions d'accésAccés restringit per acord de confidencialitat
Medical implants have been a clinical reality since many years ago and thousands of patients have been treated increasing in this way his life quality. Although many native materials have been used for bone implants, for example titanium, future biomaterials will include specific topographies and patterns on the native surface to obtain the desired function. The aim of this study is to demonstrate that human osteoblast cells are adhering differently to Al/Al2O3 nanowires depending on the density of the nanowires and consequently, on their topography. The chemistry of the nanowires is the same, while topography is different. Al/Al2O3 nanowires were fabricated by chemical vapor deposition (CVD) of the molecular precursor (tBuOAlH2)2. Three different densities; low density (LD), middle density (MD) and high density (HD), were achieved depending on the deposition time. For fast screening, transmission of the samples was measured optically. The deposited layers were characterized by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), atomic force microscope (AFM) and video contact angle-meter. The different topographies of the surfaces were tested for biocompatibility with osteoblast cells.
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