Development and evaluation of titanium content in biodegradable glass scaffolds for bone regeneration
Tutor / director / evaluatorEngel, Elisabeth,
Document typeMaster thesis
Rights accessRestricted access - author's decision
The field of Tissue Engineering has been developed in order to the replace the tissues that are lost to disease, donor tissue rejection and due to donor tissue shortages. The main aspect of Tissue Engineering is to avoid these problems by creating biological substitutes that are capable of replacing the damaged tissue. Scaffold design and development is one of the major steps of this master’s thesis. The main aim of this thesis is to develop and characterize scaffolds for Tissue Engineering applications. For this the strategy used is: 1. To study, prepare and characterize composite scaffolds processed by Solvent Casting and Salt Leaching method. 2. To characterize the microstructure and surface composition of five different formulations of Calcium Phosphate glass (CaP) P2O5–CaO–Na2O–TiO2 with 0,3,5,8 and 11 mol% of TiO2. The characterization techniques used were Scanning Electron Microscopy-Energy Dispersive Spectroscopy (SEM-EDS), X-ray diffraction (XRD), Differential Scanning Calorimetry (DSC), and Zeta Potential. 3. The degradation of different PLA-CaP glass films by selective electrode measurements. Scaffolds and membranes are made of a composite of polylactic acid (PLA) polymer and a calcium phosphate soluble glass. The compositions containing 50 weight% of glass particles and 50 weight % of PLA were chosen for preparing scaffolds and membranes further followed by characterization techniques which include degradation and surface properties. The degradation of the scaffolds was studied for a period of 2 weeks. SEM-EDS analysis is performed to obtain morphology information, elemental composition information for different CaP glasses and their scaffolds.XRD analysis gave information about the structure and phases of the CaP glasses and the glass transition temperature is obtained with the DSC analysis. The results obtained from the master’s thesis confirm the potential of biodegradable materials for a wide range of applications in regenerative medicine. However only three compositions of the total five studied gave result a bioactive glass.
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