Monte Carlo dosimetry for forthcoming clinical trials in x-ray microbeam radiation therapy
Visualitza/Obre
Estadístiques de LA Referencia / Recolecta
Inclou dades d'ús des de 2022
Cita com:
hdl:2117/9663
Tipus de documentArticle
Data publicació2010
Condicions d'accésAccés obert
Llevat que s'hi indiqui el contrari, els
continguts d'aquesta obra estan subjectes a la llicència de Creative Commons
:
Reconeixement-NoComercial-SenseObraDerivada 3.0 Espanya
Abstract
The purpose of this work is to define safe irradiation protocols in microbeam
radiation therapy. The intense synchrotron-generated x-ray beam used for the
treatment is collimated and delivered in an array of 50 μm-sized rectangular
fields with a centre-to-centre distance between microplanes of 400 μm. The
absorbed doses received by the tumour and the healthy tissues in a human
head phantom have been assessed by means of Monte Carlo simulations. The
identification of safe dose limits is carried out by evaluating the maximum peak
and valley doses achievable in the tumour while keeping the valley doses in the
healthy tissues under tolerances. As the skull receives a significant fraction of
the dose, the dose limits are referred to this tissue. Dose distributions with high
spatial resolution are presented for various tumour positions, skull thicknesses
and interbeam separations. Considering a unidirectional irradiation (field size
of 2×2 cm2) and a centrally located tumour, the largest peak and valley doses
achievable in the tumour are 55Gy and 2.6Gy, respectively. The corresponding
maximum valley doses received by the skin, bone and healthy brain are 4 Gy,
14 Gy and 7 Gy (doses in one fraction), respectively, i.e. within tolerances (5%
probability of complication within 5 years).
CitacióMartínez-Rovira, I. [et al.]. Monte Carlo dosimetry for forthcoming clinical trials in x-ray microbeam radiation therapy. "Physics in medicine and biology", 2010, vol. 55, p. 4375-4388.
ISSN0031-9155
Fitxers | Descripció | Mida | Format | Visualitza |
---|---|---|---|---|
martinezRovira2 ... Biol55p4375_MCdosimMRT.pdf | 381,5Kb | Visualitza/Obre |