DSpace DSpace UPC
 Català   Castellano   English  

E-prints UPC >
Altres >
Enviament des de DRAC >

Empreu aquest identificador per citar o enllaçar aquest ítem: http://hdl.handle.net/2117/7855

Ítem no disponible en accés obert per política de l'editorial

Arxiu Descripció MidaFormat
One-step preparation of multifunctional chitosan...pdf351,92 kBAdobe PDF Accés restringit

Citació: Skirtenko, N. [et al.]. One-step preparation of multifunctional chitosan microspheres by a simple sonochemical method. "Chemistry: a european journal", 2010, vol. 16, núm. 2, p. 562-567.
Títol: One-step preparation of multifunctional chitosan microspheres by a simple sonochemical method
Autor: Skirtenko, Natalia; Tzanov, Tzanko Veure Producció científica UPC; Gedanken, Aharon; Rahimipour, Shai
Data: 2010
Tipus de document: Article
Resum: Chitosan is a biodegradable natural polymer with great potential for pharmaceutical applications due to its biocompatibility, high charge density, nontoxicity, and mucoadhesion properties. Processing techniques for the preparation of chitosan microspheres have been extensively developed since the 1980s. The present paper describes for the first time a fast and one-step process for the preparation of stable chitosan microspheres by a simple sonochemical method. The microspheres were characterized by their particle size, surface morphology, stability, and drug-entrapment efficiency The average size of the microspheres was found to be around 1 mm with a narrow size distribution, which enabled them to be used for in vivo applications. The encapsulation of different dyes into these microspheres was readily achieved with more than 75% efficacy by dissolving them into the organic phase before sonication. The chitosan microspheres demonstrated excellent stability toward acidic and basic conditions ranging from pH 4 to 9, thereby indicating their implementation as possible therapeutic and diagnostic agents. The stability of these microspheres appears to be contributed from intermolecular imine cross-linking in addition to other noncovalent interactions. The ability of the surface-exposed amino groups of chitosan microspheres to undergo chemical conjugation with potential drugs and/or targeting vectors was determined by their reaction with fluorescein isothiocyanate (FITC) and fluorescamine followed by confocal microscopy
ISSN: 0947-6539
URI: http://hdl.handle.net/2117/7855
DOI: 10.1002/chem.200901464
Versió de l'editor: http://www3.interscience.wiley.com/journal/122684064/abstract?CRETRY=1&SRETRY=0
Apareix a les col·leccions:GBMI - Grup de Biotecnologia Molecular i Industrial. Articles de revista
Departament d'Enginyeria Química. Articles de revista
Altres. Enviament des de DRAC
Comparteix:


Stats Mostra les estadístiques d'aquest ítem

SFX Query

Tots els drets reservats. Aquesta obra està protegida pels drets de propietat intel·lectual i industrial corresponents. Sense perjudici de les exempcions legals existents, queda prohibida la seva reproducció, distribució, comunicació pública o transformació sense l'autorització del titular dels drets.

Per a qualsevol ús que se'n vulgui fer no previst a la llei, dirigiu-vos a: sepi.bupc@upc.edu

 

Valid XHTML 1.0! Programari DSpace Copyright © 2002-2004 MIT and Hewlett-Packard Comentaris
Universitat Politècnica de Catalunya. Servei de Biblioteques, Publicacions i Arxius