DSpace DSpace UPC
 Català   Castellano   English  

E-prints UPC >
Altres >
Enviament des de DRAC >

Empreu aquest identificador per citar o enllaçar aquest ítem: http://hdl.handle.net/2117/7831

Arxiu Descripció MidaFormat
journal.pone.0004872.pdf939,33 kBAdobe PDFThumbnail
Veure/Obrir

Citació: Koseska, A. [et al.]. Timing cellular decision making under noise via cell-cell communication. "PLOS one", 13 Març 2009, vol. 4, núm. 3, p. 1-6.
Títol: Timing cellular decision making under noise via cell-cell communication
Autor: Koseska, Aneta; Zaikin, Alexey; Kurths, Juergen; García Ojalvo, Jordi Veure Producció científica UPC
Data: 13-mar-2009
Tipus de document: Article
Resum: Many cellular processes require decision making mechanisms, which must act reliably even in the unavoidable presence of substantial amounts of noise. However, the multistable genetic switches that underlie most decision-making processes are dominated by fluctuations that can induce random jumps between alternative cellular states. Here we show, via theoretical modeling of a population of noise-driven bistable genetic switches, that reliable timing of decision-making processes can be accomplished for large enough population sizes, as long as cells are globally coupled by chemical means. In the light of these results, we conjecture that cell proliferation, in the presence of cell–cell communication, could provide a mechanism for reliable decision making in the presence of noise, by triggering cellular transitions only when the whole cell population reaches a certain size. In other words, the summation performed by the cell population would average out the noise and reduce its detrimental impact.
ISSN: 1932-6203
URI: http://hdl.handle.net/2117/7831
DOI: 10.1371/journal.pone.0004872
Apareix a les col·leccions:DONLL - Dinàmica no lineal, òptica no lineal i làsers. Articles de revista
Departament de Física i Enginyeria Nuclear. Articles de revista
Altres. Enviament des de DRAC
Comparteix:


Stats Mostra les estadístiques d'aquest ítem

SFX Query

Aquest ítem (excepte textos i imatges no creats per l'autor) està subjecte a una llicència de Creative Commons Llicència Creative Commons
Creative Commons

 

Valid XHTML 1.0! Programari DSpace Copyright © 2002-2004 MIT and Hewlett-Packard Comentaris
Universitat Politècnica de Catalunya. Servei de Biblioteques, Publicacions i Arxius