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Citació: Navarro, A. [et al.]. MicroRNAs expression, chromosomal alterations and immunoglobulin variable Heavy chain hypermutations in Mantle Cell Lymphomas. "Cancer research", 2009, vol. 69, núm. 17, p. 7071-7078.
Títol: MicroRNAs expression, chromosomal alterations and immunoglobulin variable Heavy chain hypermutations in Mantle Cell Lymphomas
Autor: López-Guillermo, A; Navarro, A; Beà, Sílvia; Fernández, V; Prieto, M; Salaverria, I; Jares, P; Hartmann, E; Mozos, A; Hernández, L; Campo, E; Rossenwald, A; Serrano, Sergi; Solé Parellada, Francesc Veure Producció científica UPC; Ott, G; Puig Oriol, Xavier Veure Producció científica UPC; Colomer, D; Villamor, N.
Data: 2009
Tipus de document: Article
Resum: The contribution of microRNAs (miR) to the pathogenesis of mantle cell lymphoma (MCL) is not well known.We investigated the expression of 86 mature miRs mapped to frequently altered genomic regions in MCL in CD5+/CD5 normal B cells, reactive lymph nodes, and purified tumor cells of 17 leukemic MCL, 12 nodal MCL, and 8MCL cell lines. Genomic alterations of the tumors were studied by single nucleotide polymorphism arrays and comparative genomic hybridization. Leukemic and nodal tumors showed a high number of differentially expressed miRs compared with purified normal B cells, but only some of them were commonly deregulated in both tumor types. An unsupervised analysis of miR expression profile in purified leukemic MCL cells revealed two clusters of tumors characterized by different mutational status of the immunoglobulin genes, proliferation signature, and number of genomic alterations. The expression of most miRs was not related to copy number changes in their respective chromosomal loci. Only the levels of miRs included in the miR-17-92 cluster were significantly related to genetic alterations at 13q31. Moreover, overexpression of miR-17-5p/miR-20a from this cluster was associated with high MYC mRNA levels in tumors with a more aggressive behavior. In conclusion, the miR expression pattern of MCL is deregulated in comparison with normal lymphoid cells and distinguishes two subgroups of tumors with different biological features.
ISSN: 0008-5472
URI: http://hdl.handle.net/2117/6957
Versió de l'editor: http://cancerres.aacrjournals.org/cgi/reprint/69/17/7071.pdf
Apareix a les col·leccions:GRESA - Grup de recerca en estadística aplicada. Articles de revista
Departament d'Estadística i Investigació Operativa. Articles de revista
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