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Citació: Solé, X. [et al.]. Biological convergence of cancer signatures. "PLOS one", 18 Setembre 2009, vol. 4, núm. 2.
Títol: Biological convergence of cancer signatures
Autor: Pujana, Miguel Angel; Moreno Fernández, Mario Victor Veure Producció científica UPC; Capellá Frau, Gabriel José Veure Producció científica UPC; Comellas Padró, Francesc de Paula Veure Producció científica UPC; Sanjosé, Silvia de; Urruticoechea, Ander; Solé, Xavier; Bonifaci, Núria; López Bigas, Núria; Berenguer, Antoni; Hernández, Pilar; Reina, Oscar; Maxwell, Christopher A.; Aguilar, Helena
Data: 18-set-2009
Tipus de document: Article
Resum: Gene expression profiling has identified cancer prognostic and predictive signatures with superior performance to conventional histopathological or clinical parameters. Consequently, signatures are being incorporated into clinical practice and will soon influence everyday decisions in oncology. However, the slight overlap in the gene identity between signatures for the same cancer type or condition raises questions about their biological and clinical implications. To clarify these issues, better understanding of the molecular properties and possible interactions underlying apparently dissimilar signatures is needed. Here, we evaluated whether the signatures of 24 independent studies are related at the genome, transcriptome or proteome levels. Significant associations were consistently observed across these molecular layers, which suggest the existence of a common cancer cell phenotype. Convergence on cell proliferation and death supports the pivotal involvement of these processes in prognosis, metastasis and treatment response. In addition, functional and molecular associations were identified with the immune response in different cancer types and conditions that complement the contribution of cell proliferation and death. Examination of additional, independent, cancer datasets corroborated our observations. This study proposes a comprehensive strategy for interpreting cancer signatures that reveals common design principles and systems-level properties.
ISSN: 1932-6203
URI: http://hdl.handle.net/2117/6540
DOI: 10.1371/journal.pone.0004544
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